Evidence map›Paper›PMID 39651240›Full record

ArticlebioRxiv : the preprint server for biology2025

Single cell RNA-sequencing reveals no evidence for meiotic sex chromosome inactivation in the threespine stickleback fish.

Daniel E Shaw, Wynter D Ross, Alexis V Lambert, Michael A White

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Daniel E ShawDepartment of Genetics, University of Georgia, Athens, GA, 30602.ORCID 0000-0001-8838-304X
Wynter D RossDepartment of Genetics, University of Georgia, Athens, GA, 30602.
Alexis V LambertDepartment of Genetics, University of Georgia, Athens, GA, 30602.
Michael A WhiteDepartment of Genetics, University of Georgia, Athens, GA, 30602.ORCID 0000-0001-6772-1388

Funding

Supplement: Functional Analysis of the Anti-Müllerian Hormone as a Convergently Acquired Master Sex Determination GeneR01GM147312 · NIGMS · UNIVERSITY OF GEORGIA · PI Michael Andrew White · 2023 to 2026
$1.4M
NIGMS NIH HHS R01 GM147312
6 · The paper itself

Abstract

Sex chromosomes often evolve unique patterns of gene expression during spermatogenesis. In many species, sex-linked genes are downregulated during meiosis in response to asynapsis of the heterogametic sex chromosome pair (meiotic sex chromosome inactivation; MSCI). This process has evolved convergently across many taxa with independently derived sex chromosomes. Our understanding how quickly MSCI can evolve and whether it is connected to the degree of sequence degeneration remains limited. Teleost fish are a noteworthy group to investigate MSCI because sex chromosomes have evolved repeatedly across species, often over short evolutionary timescales. Here, we investigate whether MSCI occurs in the threespine stickleback fish (

Identifiers

PMID39651240
PMCPMC11623615

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.