Evidence map›Paper›PMID 39651235›Full record

ArticlebioRxiv : the preprint server for biology2024

Saccharibacteria deploy two distinct Type IV pili, driving episymbiosis, host competition, and twitching motility.

Alex S Grossman, Lei Lei, Jack M Botting, Jett Liu, Nusrat Nahar, João Gabriel S Souza, Jun Liu, Jeffrey S McLean, Xuesong He, Batbileg Bor

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Alex S GrossmanDepartment of Microbiology, ADA Forsyth Institute, Cambridge MA, 02142, USA.ORCID 0000-0003-1661-0383
Lei LeiDepartment of Microbiology, ADA Forsyth Institute, Cambridge MA, 02142, USA.ORCID 0000-0002-0125-0904
Jack M BottingDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven CT, 06536, United States.ORCID 0009-0002-7304-3936
Jett LiuDepartment of Microbiology, ADA Forsyth Institute, Cambridge MA, 02142, USA.ORCID 0000-0001-7048-4248
Nusrat NaharDepartment of Microbiology, ADA Forsyth Institute, Cambridge MA, 02142, USA.
João Gabriel S SouzaDepartment of Microbiology, ADA Forsyth Institute, Cambridge MA, 02142, USA.ORCID 0000-0001-5944-6953
Jun LiuDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven CT, 06536, United States.
Jeffrey S McLeanDepartment of Microbiology, University of Washington, Seattle WA, 98109, USA.ORCID 0000-0001-9934-5137
Xuesong HeDepartment of Microbiology, ADA Forsyth Institute, Cambridge MA, 02142, USA.
Batbileg BorDepartment of Microbiology, ADA Forsyth Institute, Cambridge MA, 02142, USA.ORCID 0000-0002-1797-1730

Funding

Domestication and characterization of TM7-the most elusive oral phylumR01DE023810 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xuesong He, Jeffrey Scott McLean · 2014 to 2026
$6.6M
Forsyth Training in Oral Health ResearchT90DE026110 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI THOMAS Elliott VAN DYKE · 2017 to 2026
$3.0M
Functional and Structural Analysis of the Dot/Icm Type IVB Secretion MachineR01AI152421 · NIAID · YALE UNIVERSITY · PI LIU, JUN, ROY, CRAIG R. · 2020 to 2024
$2.9M
Impact of Saccharibacteria and their bacterial hosts in Periodontal and Inflammatory DiseasesR01DE031274 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI Batbileg Bor · 2022 to 2026
$2.5M
High-throughput electron cryo-microscopeS10OD023603 · OD · YALE UNIVERSITY · PI SIGWORTH, FREDERICK J · 2018 to 2018
$1.9M
Spectral Confocal Imaging Instrumentation for Forsyth Advanced Microscopy Core S10OD034405 · OD · ADA FORSYTH INSTITUTE, INC. · PI BORISY, GARY G · 2023 to 2023
$600k
NIAID NIH HHS R01 AI152421NIDCR NIH HHS R01 DE023810NIDCR NIH HHS R01 DE031274NIDCR NIH HHS T90 DE026110NIH HHS S10 OD023603NIH HHS S10 OD034405
6 · The paper itself

Abstract

All cultivated Patescibacteria, or CPR, exist as obligate episymbionts on other microbes. Despite being ubiquitous in mammals and environmentally, molecular mechanisms of host identification and binding amongst ultrasmall bacterial episymbionts are largely unknown. Type 4 pili (T4P) are well conserved in this group and predicted to facilitate symbiotic interactions. To test this, we targeted T4P pilin genes in Saccharibacteria

Identifiers

PMID39651235
PMCPMC11623550

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.