Evidence map›Paper›PMID 39651225›Full record

ArticlebioRxiv : the preprint server for biology2024

Sensory Entrained TMS (seTMS) enhances motor cortex excitability.

Jessica M Ross, Lily Forman, Juha Gogulski, Umair Hassan, Christopher C Cline, Sara Parmigiani, Jade Truong, James W Hartford, Nai-Feng Chen, Takako Fujioka and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Jessica M RossDepartment of Psychiatry and Behavioral Sciences, Stanford University Medical Center, 401 Quarry Road, Stanford, CA, 94305, USA.ORCID 0000-0002-7487-8946
Lily FormanDepartment of Psychiatry and Behavioral Sciences, Stanford University Medical Center, 401 Quarry Road, Stanford, CA, 94305, USA.
Juha GogulskiDepartment of Psychiatry and Behavioral Sciences, Stanford University Medical Center, 401 Quarry Road, Stanford, CA, 94305, USA.ORCID 0000-0001-7179-7828
Umair HassanDepartment of Psychiatry and Behavioral Sciences, Stanford University Medical Center, 401 Quarry Road, Stanford, CA, 94305, USA.
Christopher C ClineDepartment of Psychiatry and Behavioral Sciences, Stanford University Medical Center, 401 Quarry Road, Stanford, CA, 94305, USA.ORCID 0000-0003-1442-8641
Sara ParmigianiDepartment of Psychiatry and Behavioral Sciences, Stanford University Medical Center, 401 Quarry Road, Stanford, CA, 94305, USA.
Jade TruongDepartment of Psychiatry and Behavioral Sciences, Stanford University Medical Center, 401 Quarry Road, Stanford, CA, 94305, USA.
James W HartfordDepartment of Psychiatry and Behavioral Sciences, Stanford University Medical Center, 401 Quarry Road, Stanford, CA, 94305, USA.
Nai-Feng ChenDepartment of Psychiatry and Behavioral Sciences, Stanford University Medical Center, 401 Quarry Road, Stanford, CA, 94305, USA.
Takako FujiokaCenter for Computer Research in Music and Acoustics (CCRMA), Department of Music, Stanford University, Stanford, CA, USA.
Scott MakeigSwartz Center for Computational Neuroscience, Institute for Neural Computation, University of California, San Diego, CA, USA.
Alvaro Pascual-LeoneDepartment of Neurology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8975-0382
Corey J KellerDepartment of Psychiatry and Behavioral Sciences, Stanford University Medical Center, 401 Quarry Road, Stanford, CA, 94305, USA.ORCID 0000-0003-0529-3490

Funding

Closing the loop: development of real-time, personalized brain stimulationR01MH126639 · NIMH · STANFORD UNIVERSITY · PI KELLER, COREY J · 2021 to 2024
$1.6M
NIMH NIH HHS R01 MH126639
6 · The paper itself

Abstract

Transcranial magnetic stimulation (TMS) applied to the motor cortex has revolutionized the study of motor physiology in humans. Despite this, TMS-evoked electrophysiological responses show significant variability, due in part to inconsistencies between TMS pulse timing and ongoing brain oscillations. Variable responses to TMS limit mechanistic insights and clinical efficacy, necessitating the development of methods to precisely coordinate the timing of TMS pulses to the phase of relevant oscillatory activity. We introduce Sensory Entrained TMS (seTMS), a novel approach that uses musical rhythms to synchronize brain oscillations and time TMS pulses to enhance cortical excitability. Focusing on the sensorimotor alpha rhythm, a neural oscillation associated with motor cortical inhibition, we examine whether rhythm-evoked sensorimotor alpha phase alignment affects primary motor cortical (M1) excitability in healthy young adults (

Indexed as

Electroencephalogram (EEG)Motor Evoked Potential (MEP)Non-invasive brain stimulation (NIBS)Transcranial magnetic stimulation (TMS)

Identifiers

PMID39651225
PMCPMC11623581

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.