ArticleCureus2024
Precision Diagnosis of Viral Respiratory Infections: Unleashing the Power of Multiplex Polymerase Chain Reaction (PCR) for Enhanced Infection Management.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Viral Respiratory Infections and Host Immune Dynamics in Diabetes: Clinical Outcomes in the Post-COVID Era.Microorganisms · 2026Article
- Changes in Respiratory Viruses' Activity in Children During the COVID-19 Pandemic: A Systematic Review.Journal of clinical medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundViruses are key agents causing respiratory illnesses, creating significant public health challenges worldwide. Timely identification of the responsible pathogen is crucial for effective patient management. Conventional virus detection methods in laboratories are often laborious and time-consuming, prompting the need for more efficient diagnostic techniques. The multiplex polymerase chain reaction (PCR) method, capable of testing multiple pathogens simultaneously, offers a promising solution.
objectiveThis study investigates the efficacy of multiplex PCR, specifically using the BioFire FilmArray Respiratory Panel (RP2.1), in diagnosing viral respiratory infections and its impact on patient outcomes.
methodsA retrospective study was conducted at the Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, from January 2022 to December 2023, involving 36 patients with upper respiratory tract infection symptoms. Nasopharyngeal and oropharyngeal swabs were collected and tested using the BioFire FilmArray RP2.1, targeting 17 viruses and four bacteria.
resultsAmong the 36 samples, 21 (58.33%) exhibited viral agents, with human rhinovirus/enterovirus being the most prevalent (19.44%). Respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), and influenza B were commonly identified. The study found a single viral etiology in 17 samples (47.22%), dual infections in two samples (5.56%), and triple infections in two samples (5.56%). Patient outcomes varied, with seven recorded deaths, mainly among ICU patients. SARS-CoV-2 was a prominent cause of mortality. Most patients with viral respiratory illnesses were from the pediatric (27.78%) and elderly (19.44%) age groups.
conclusionThe BioFire FilmArray RP2.1 is a valuable tool for rapid and accurate diagnosis of respiratory infections, facilitating timely and appropriate medical interventions. Despite its higher cost, its efficiency in diagnosis and potential to reduce unnecessary treatments highlight its cost-effectiveness in clinical settings.
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Registered trials
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