ArticleCureus2024
Marchiafava-Bignami Disease: A Case Report of a Reversible Cause of Dementia.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Marchiafava-Bignami disease (MBD) is a rare neurological disorder predominantly associated with chronic alcohol use, characterized by demyelination and necrosis of the corpus callosum. The condition often presents with cognitive dysfunction, motor deficits, and altered consciousness, which can range from mild confusion to severe stupor. Early recognition and treatment are crucial for improving outcomes. We report a case of MDB that was diagnosed in a 43-year-old woman with a history of chronic alcohol use and a 15-day history of progressive neurological symptoms, including impaired speech, confusion, and inability to walk independently. Brain MRI findings were consistent with MBD, showing acute demyelination of the anterior corpus callosum. The patient was treated with high-dose intravenous thiamine and B vitamins, resulting in a gradual and significant improvement. After one month, she regained coherent speech and the ability to walk independently.
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