Evidence map›Paper›PMID 39650856›Full record

ArticleThe journal of poultry science2024

Effects of Synthetic CpG Oligodeoxynucleotide K3 on Immune Response, Behavior, and Physiology in Male Layer Chicks (

Tetsuya Tachibana, Rena Mimura, Sakirul Khan, Mark A Cline

Abstract read
In one paragraph

Article in The journal of poultry science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tetsuya TachibanaDepartment of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama 790-8566, Japan.
Rena MimuraDepartment of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama 790-8566, Japan.
Sakirul KhanResearch Center for Global and Local Infectious Diseases, Oita University, Yufu, Oita 879-5593, Japan.
Mark A ClineSchool of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg 24061, Virginia, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unmethylated cytosine-phosphate-guanine (CpG) motifs are often found in bacteria and viruses, but are rare in mammals. In mammals, CpG oligodeoxynucleotides (CpG ODN) stimulate the innate immune system via toll-like receptor 9 (TLR9). However, TLR9 is absent in birds; instead, TLR21 serves as the receptor for CpG ODN. While CpG ODN induce behavioral and physiological changes in mammals, there is limited research on their effects on behavioral and physiological parameters in birds. The aim of the present study was to determine whether intraperitoneal injection of K3, a synthetic class B CpG ODN, affected food intake, voluntary activity, cloacal temperature, blood constituents, and feed passage from the crop in chicks (

Indexed as

chicksclass B CpG oligonucleotidecloacal temperaturecrop emptyingfeeding

Identifiers

PMID39650856
PMCPMC11611325

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.