Evidence map›Paper›PMID 39650800›Full record

ArticleNature. Mental health2024

Latent mechanisms of language disorganization relate to specific dimensions of psychopathology.

Isaac Fradkin, Rick A Adams, Noam Siegelman, Rani Moran, Raymond J Dolan

Abstract read
In one paragraph

Article in Nature. Mental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Naturalistic computational psychiatry: How to get there?Journal of psychiatry & neuroscience : JPN
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Isaac FradkinMax Planck University College London Centre for Computational Psychiatry and Ageing Research, London, UK.ORCID 0000-0002-6387-1941
Rick A AdamsMax Planck University College London Centre for Computational Psychiatry and Ageing Research, London, UK.ORCID 0000-0002-7661-8881
Noam SiegelmanDepartment of Psychology, Hebrew University of Jerusalem, Jerusalem, Israel.
Rani Moran *Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London, UK.ORCID 0000-0002-7641-2402
Raymond J Dolan *Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London, UK.ORCID 0000-0001-9356-761X

Funding

Wellcome Trust
6 · The paper itself

Abstract

Comprehensible communication is critical for social functioning and well-being. In psychopathology, incoherent discourse is assumed to reflect disorganized thinking, which is classically linked to psychotic disorders. However, people do not express everything that comes to mind, rendering inferences from discourse to the underlying structure of thought challenging. Indeed, a range of psychopathologies are linked to self-reported disorganized thinking in the absence of language output incoherence. Here we combine natural language processing and computational modeling of free association to detail the relationship between disorganized thinking and language (in)coherence in a large sample of participants varying across different dimensions of psychopathology. Our approach allowed us to differentiate between disorganized thinking, disinhibited thought expression and deliberate creativity. We find evidence for both under-regulated and over-regulated disorganized thinking, which relate to two specific dimensions of psychopathology: self-reported eccentricity and suspiciousness. Broadly, these results underscore the theoretical progress afforded by analyzing latent dimensions underlying behavior and psychopathology.

Indexed as

Computational neuroscienceLanguagePsychiatric disordersPsychologyPsychosis

Identifiers

PMID39650800
PMCPMC11621019

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.