Evidence map›Paper›PMID 39650739›Full record

ArticleRSC pharmaceutics2025

Microfluidics-generated PLA nanoparticles: impact of purification method on macrophage interactions, anti-inflammatory effects, biodistribution, and protein corona formation.

Jacob R Shaw, Radha Vaidya, Fanny Xu, Shruti Dharmaraj, Ryan M Pearson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jacob R ShawDepartment of Microbiology and Immunology, University of Maryland School of Medicine 685 W. Baltimore Street Baltimore MD 21201 USA.ORCID https://orcid.org/0000-0002-5885-1006
Radha VaidyaDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy 20 N. Pine Street Baltimore MD 21201 USA rpearson@rx.umaryland.edu +410-706-3257.ORCID https://orcid.org/0009-0007-5901-8191
Fanny XuDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy 20 N. Pine Street Baltimore MD 21201 USA rpearson@rx.umaryland.edu +410-706-3257.ORCID https://orcid.org/0009-0002-4986-2632
Shruti DharmarajDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy 20 N. Pine Street Baltimore MD 21201 USA rpearson@rx.umaryland.edu +410-706-3257.
Ryan M PearsonDepartment of Microbiology and Immunology, University of Maryland School of Medicine 685 W. Baltimore Street Baltimore MD 21201 USA.ORCID https://orcid.org/0000-0002-7857-0973

Funding

UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANTP30CA134274 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI FEYRUZ VIRGILIA RASSOOL · 2008 to 2026
$51.0M
Polymeric nanoassemblies for precise tuning of immune responses (Supplement for Equipment Purchase)R35GM142752 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI PEARSON, RYAN MATTHEW · 2021 to 2025
$2.1M
In Vivo Fluorescence and Bioluminescence Imager with CTS10OD030430 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI LAPIDUS, RENA · 2021 to 2021
$600k
NCI NIH HHS P30 CA134274NIGMS NIH HHS R35 GM142752NIH HHS S10 OD030430
6 · The paper itself

Abstract

Polymeric nanoparticles (NPs) are traditionally formulated using batch methodologies that are poorly scalable and require time consuming, hands-on purification procedures. Here, we prepared poly(lactic acid) (PLA)-based polymeric NPs using a scalable microfluidics-based method and systematically investigated the impact of purification method (centrifugation

Identifiers

PMID39650739
PMCPMC11615567

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.