Evidence map›Paper›PMID 39650737›Full record

ArticleiScience2024

Altered m6A RNA methylation profiles in depression implicate the dysregulation of discrete cellular functions in males and females.

Haruka Mitsuhashi, Rixing Lin, Anjali Chawla, Naguib Mechawar, Corina Nagy, Gustavo Turecki

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. mNature reviews. Neuroscience · 2026
    Review
  3. Review
  4. Obesity-related RNA mJournal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. The expressions and mFrontiers in genetics · 2026
    Article
  11. mEpigenomes · 2025
    Review
  12. MNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haruka MitsuhashiMcGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, QC H4H 1R3, Canada.
Rixing LinPrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544 USA, USA.
Anjali ChawlaMcGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, QC H4H 1R3, Canada.
Naguib MechawarMcGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, QC H4H 1R3, Canada.
Corina NagyMcGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, QC H4H 1R3, Canada.
Gustavo TureckiMcGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, QC H4H 1R3, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adverse environmental stress represents a significant risk factor for major depressive disorder (MDD), often resulting in disrupted synaptic connectivity which is known to be partly regulated by epigenetic mechanisms. N

Indexed as

biological scienceshealth sciencesmedical specialtymedicinenatural sciencesomicspsychiatry

Identifiers

PMID39650737
PMCPMC11625292

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.