Evidence map›Paper›PMID 39650644›Full record

ArticleFrontiers in immunology2024

Emmanuelle Giuliana Mendes Santana, Fabiane Dos Santos Ferreira, Wandrey Roberto Dos Santos Brito, Felipe Teixeira Lopes, Aline Cecy Rocha de Lima, Gabriel Dos Santos Pereira Neto, Ednelza da Silva Graça Amoras, Sandra Souza Lima, Carlos Araujo da Costa, Maísa Silva Souza and 4 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. The X-LinkedInternational journal of molecular sciences · 2025
    Article
  5. Review
  6. Frontiers in cellular and infection microbiology · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Emmanuelle Giuliana Mendes Santana *Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Fabiane Dos Santos Ferreira *Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Wandrey Roberto Dos Santos BritoLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Felipe Teixeira LopesLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Aline Cecy Rocha de LimaLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Gabriel Dos Santos Pereira NetoLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Ednelza da Silva Graça AmorasLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Sandra Souza LimaLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Carlos Araujo da CostaLaboratory of Cellular and Molecular Biology, Tropical Medicine Center, Federal University of Pará, Belém, Brazil.
Maísa Silva SouzaLaboratory of Cellular and Molecular Biology, Tropical Medicine Center, Federal University of Pará, Belém, Brazil.
Ricardo IshakLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Izaura Maria Vieira Cayres-VallinotoLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Antonio Carlos Rosário VallinotoLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Maria Alice Freitas QueirozLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: TLR7 detects the presence of single-stranded RNA (ssRNA) viruses, including human T-lymphotropic virus 1 (HTLV-1), and triggers antiviral and inflammatory responses that are responsible for infection control. Genetic variations in the Methods: Blood samples from 159 individuals with HTLV-1 infection (66 with inflammatory diseases and 93 asymptomatic individuals) and 159 controls were collected. The genotyping of polymorphisms, TLR7 gene expression analysis and the quantification of the proviral load were performed by real-time PCR, and cytokine measurement was performed by enzyme-linked immunosorbent assay (ELISA). Results: Carriers of the polymorphic allele for Discussion: Although the polymorphisms did not influence the presence of symptoms of diseases caused by HTLV-1, carriers of the wild-type alleles for

Indexed as

HTLV-I InfectionsHuman T-lymphotropic virus 1Interferon-alphaPolymorphism, Single NucleotideToll-Like Receptor 7Viral LoadAdultAgedAllelesCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedInterferon-alphaTLR7 protein, humanToll-Like Receptor 7gene expression profileHTLV-I infectioninterferon-alphapolymorphism genetictoll-like receptor 7

Identifiers

PMID39650644
PMCPMC11621001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.