Evidence map›Paper›PMID 39650613›Full record

ArticleCase reports in otolaryngology2024

Exploring Potential Orbital Metastatic Pathways in Sinonasal Mucosal Melanoma: A Case Report.

W F Julius Scheurleer, W Weibel Braunius, M de Ridder, Eduard H J Voormolen, Remco de Bree, Ronald L A W Bleys, Rachel Kalmann, Gerben E Breimer, Johannes A Rijken

Abstract readCase Reports
In one paragraph

Article in Case reports in otolaryngology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

W F Julius ScheurleerDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0002-6801-106X
W Weibel BrauniusDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0002-3580-1890
M de RidderDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0002-2530-3038
Eduard H J VoormolenDepartment of Neurosurgery, University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0002-1273-7208
Remco de BreeDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0001-7128-5814
Ronald L A W BleysDepartment of Anatomy, University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0002-5408-038X
Rachel KalmannDepartment of Ophthalmology, University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0001-7038-4554
Gerben E BreimerDepartment of Pathology, University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0003-0365-3667
Johannes A RijkenDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0002-4579-3249

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The following case potentially provides insight into the mechanisms of lymphogenic metastasis in sinonasal cancer. A 63-year-old patient who presented with progressive diplopia and left-sided periocular pain was diagnosed with a cT4bN0M0 mucosal melanoma of the ethmoid sinus. She underwent a combined endonasal and transcranial tumor resection, and an orbital exenteration. Upon histopathological examination, besides the primary tumor, two separate localizations of melanoma surrounded by lymphoid tissues and lymph follicles were identified. The tumor was upstaged to pT4bN1, and the patient received a combination of adjuvant immunotherapy and radiotherapy. At present, the patient displays no evidence of disease. The presence of orbital lymph nodes has previously never been confirmed. These findings indicate the potential involvement of lymphatic drainage through the retrobulbar fat in the regional spread of sinonasal tumors closely associated with the orbit.

Indexed as

lymph node metastasesmucosal melanomaparanasal sinus neoplasmsinonasal cancer

Identifiers

PMID39650613
PMCPMC11625083

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.