Evidence map›Paper›PMID 39650284›Full record

ArticleBrain, behavior, & immunity - health2024

Genetic association of the kynurenine pathway to suicidal behavior.

Rabah Tamimou, Christine Montout, Thibault Mura, Ismael Conejero, Alexandre Evrard, Philippe Courtet, Pablo Bonilla-Escribano, Carlos Riaza, Concepción Vaquero-Lorenzo, Enrique Baca-Garcia and 4 more

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In one paragraph

Article in Brain, behavior, & immunity - health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rabah TamimouDepartment of Psychiatry, Nîmes University Hospital, Nîmes, France.
Christine MontoutDepartment of Biostatistics, Epidemiology, Public Health and Innovation in Methodology, CHU Nîmes, University of Montpellier, Nîmes, France.
Thibault MuraDepartment of Biostatistics, Epidemiology, Public Health and Innovation in Methodology, CHU Nîmes, University of Montpellier, Nîmes, France.
Ismael ConejeroDepartment of Psychiatry, Nîmes University Hospital, Nîmes, France.
Alexandre EvrardLaboratory of Biochemistry and Molecular Biology, Nimes University Hospital and INSERM U1194, Institute of Cancer Research of Montpellier, Montpellier, France.
Philippe CourtetIGF, Univ. Montpellier, CNRS, INSERM, Montpellier, France.
Pablo Bonilla-EscribanoCentro de Tecnología Biomédica, Polytechnic University of Madrid, Madrid, Spain.
Carlos RiazaHospital universitario Ramon y Cajal, Servicio de Psiquiatría, Madrid, Spain.
Concepción Vaquero-LorenzoCentro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain.
Enrique Baca-GarciaCentro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain.
Fabrice JollantDepartment of Psychiatry, Nîmes University Hospital, Nîmes, France.
Serge LumbrosoLaboratory of Biochemistry and Molecular Biology, Nimes University Hospital, INM, University of Montpellier, INSERM, Montpellier, France.
Kevin MouzatLaboratory of Biochemistry and Molecular Biology, Nimes University Hospital, INM, University of Montpellier, INSERM, Montpellier, France.
Jorge Lopez-CastromanDepartment of Psychiatry, Nîmes University Hospital, Nîmes, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Suicidal behavior has been associated with dysfunctions in the kynurenine pathway, including alterations in the levels of neuroprotective and neurotoxic metabolites. Changes in the catalytic activity of enzymes within the pathway may contribute significantly. Variations in the genes encoding enzymes within the pathway can significantly affect their catalytic activity, playing a crucial role in the process. To explore this possibility, we hypothesized that these genetic variations would occur more frequently in patients with a history of suicidal behavior compared to non-suicidal individuals. Thus, we investigated the relationship between a history of suicide attempts and five single nucleotide polymorphisms (SNPs) within genes involved in the kynurenine pathway:

Identifiers

PMID39650284
PMCPMC11625281

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.