Evidence map›Paper›PMID 39650276›Full record

ArticleSovremennye tekhnologii v meditsine2024

Nanoparticles for Creating a Strategy to Stimulate Liver Regeneration.

S A Rodimova, D S Kozlov, D P Krylov, L V Mikhailova, V A Kozlova, A I Gavrina, A M Mozherov, V V Elagin, D S Kuznetsova

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Article in Sovremennye tekhnologii v meditsine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

S A RodimovaJunior Researcher, Research Laboratory of Regenerative Medicine; Research Laboratory of Molecular Biotechnologies, Institute of Experimental Oncology and Biomedical Technologies; The Institute of Experimental Medicine, 12 Akademika Pavlova St., Saint Petersburg, 197376, Russia.
D S KozlovLaboratory Assistant, Research Laboratory of Molecular Biotechnologies, Institute of Experimental Oncology and Biomedical Technologies; The Institute of Experimental Medicine, 12 Akademika Pavlova St., Saint Petersburg, 197376, Russia; Student; National Research Lobachevsky State University of Nizhny Novgorod, 23 Prospekt Gagarina, Nizhny Novgorod, 603022, Russia.
D P KrylovLaboratory Assistant, Research Laboratory of Molecular Biotechnologies, Institute of Experimental Oncology and Biomedical Technologies; The Institute of Experimental Medicine, 12 Akademika Pavlova St., Saint Petersburg, 197376, Russia Student; National Research Lobachevsky State University of Nizhny Novgorod, 23 Prospekt Gagarina, Nizhny Novgorod, 603022, Russia.
L V MikhailovaEngineer, Department of Physics; ITMO University (Saint Petersburg National Research University of Information Technologies, Mechanics and Optics), 49 Kronverksky Pr., Saint Petersburg, 197101, Russia.
V A KozlovaStudent; National Research Lobachevsky State University of Nizhny Novgorod, 23 Prospekt Gagarina, Nizhny Novgorod, 603022, Russia.
A I GavrinaJunior Researcher, Research Laboratory of Molecular Biotechnologies, Institute of Experimental Oncology and Biomedical Technologies; The Institute of Experimental Medicine, 12 Akademika Pavlova St., Saint Petersburg, 197376, Russia.
A M MozherovJunior Researcher, Research Laboratory of Optical Spectroscopy and Microscopy, Institute of Experimental Oncology and Biomedical Technologies; The Institute of Experimental Medicine, 12 Akademika Pavlova St., Saint Petersburg, 197376, Russia.
V V ElaginPhD, Researcher, Research Laboratory of Optical Spectroscopy and Microscopy; Research Laboratory of Molecular Biotechnologies, Institute of Experimental Oncology and Biomedical Technologies; The Institute of Experimental Medicine, 12 Akademika Pavlova St., Saint Petersburg, 197376, Russia.
D S KuznetsovaPhD, Head of the Research Laboratory of Molecular Biotechnologies, Institute of Experimental Oncology and Biomedical Technologies; The Institute of Experimental Medicine, 12 Akademika Pavlova St., Saint Petersburg, 197376, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Presently, there is a need in the developing new approaches to stimulate liver regeneration, which would make its recovery more effective after resection. Application of nanoparticles, loaded with small bioactive molecules, with their targeted delivery into the liver is a promising approach. Materials and Methods: Nanoparticles have been synthetized from polylactide (PLA), gold (Au), and silicon (SiO Results: The silicon nanoparticles are accumulated mainly by macrophages, which generate reactive oxygen species in a large amount and impair the native metabolic state of hepatocytes. The gold nanoparticles accumulate in all types of the liver cells but possess a marked toxic effect, which is indicated by the appearance of necrotic and apoptotic cells and a sharp change in the hepatocyte metabolic state. The polylactide nanoparticles accumulate most effectively in the liver cells, preferably in hepatocytes, do not change their native metabolic state, making this type of nanoparticles most promising for creating the bioactive molecule delivery systems to stimulate liver regeneration.

Indexed as

GoldHepatocytesLiver RegenerationNanoparticlesPolyestersAnimalsHumansLiverMetal NanoparticlesSilicon DioxideGoldPolyesterspoly(lactide)Silicon DioxidebiodistributionFLIMliver cell cultureliver regenerationliver slicesnanoparticles

Identifiers

PMID39650276
PMCPMC11618528

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