ArticleThe World Allergy Organization journal2024
Levels of total IgE versus specific IgE during childhood for defining and predicting T2-high asthma.
Article in The World Allergy Organization journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Early predictors of persistent childhood asthma and allergic rhinitis: A machine learning study using post-hoc explainability.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Biomarkers of Treatment-Escalation Risk by Obesity Status in Pediatric Asthma: A Development and External Validation Cohort Study.Children (Basel, Switzerland) · 2026Article
- Non-syndromic elevated IgE.The World Allergy Organization journal · 2026Article
- Article
- Effects of T2-high asthma heterogeneity and inhaled corticosteroid on airway and metabolic profiles: A multi-omic approach.Journal of translational internal medicine · 2026Article
- The association of peripheral blood inflammatory markers with the distribution patterns of IgE in children with allergen sensitization.BMC immunology · 2025Article
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Authors and funding
8 authors.
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Abstract
Background: T2-high asthma is characterized by elevated blood eosinophils (b-eos), and/or fractional exhaled nitric oxide (FeNO), and/or being "allergy-driven", which is not well-defined. Objective: To investigate the role of total and specific immunoglobulin E (tIgE/sIgE) for defining and predicting T2-high asthma in childhood as biomarkers of "allergy-driven". Methods: We utilized data from the COPSAC2000 (n = 411) and COPSAC2010 (n = 700) mother-child cohorts with repeated measurements of tIgE, sIgE, b-eos and FeNO through childhood. We defined T2-high asthma by elevated b-eos (≥0.3 × 10 Results: Elevated tIgE was associated with risk of T2-high asthma at all time points, whereas elevated sIgE showed similar results at ages 10/13/18 years. There was no overall model fit preference for a combination of tIgE and sIgE instead of tIgE or sIgE alone using Vuong's Likelihood-Ratio-Test, Akaike or Bayesian Information Criterion. Further, elevated tIgE at age 0-4 years was associated with later risk of T2-high asthma at all time points (AUC = 0.63-0.70, sensitivity = 0.62-0.81, specificity = 0.57-0.78), whereas elevated sIgE at 0-4 years was only associated with T2-high asthma at 18 years (AUC = 0.66, sensitivity = 0.45, specificity = 0.88). There were no significant differences in AUC values between tIgE and sIgE (DeLong's test). Conclusion: Elevated tIgE and sIgE are equally useful stand-alone biomarkers for defining and predicting risk of T2-high asthma in childhood.
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