Evidence map›Paper›PMID 39649740›Full record

ArticleThe Canadian veterinary journal = La revue veterinaire canadienne2024

Retrospective evaluation of the influence of phenoxybenzamine pretreatment on intraoperative cardiovascular variables in dogs with pheochromocytoma.

Craig Willette, Gianluca Bini, Marine Traverson, Julius M Liptak, Danielle Hollenbeck, Elizabeth A Maxwell, Carlos H de Mello Souza, Brandan Wustefeld-Janssens, Laura Selmic

Abstract read
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Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Craig WilletteDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA (Willette); Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA (Bini, Selmic); Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA (Traverson); Capital City Specialty & Emergency Animal Hospital, Ottawa, Ontario (Liptak); College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA (Hollenbeck); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA (Maxwell, de Mello Souza); College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA (Wustefeld-Janssens).
Gianluca BiniDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA (Willette); Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA (Bini, Selmic); Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA (Traverson); Capital City Specialty & Emergency Animal Hospital, Ottawa, Ontario (Liptak); College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA (Hollenbeck); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA (Maxwell, de Mello Souza); College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA (Wustefeld-Janssens).
Marine TraversonDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA (Willette); Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA (Bini, Selmic); Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA (Traverson); Capital City Specialty & Emergency Animal Hospital, Ottawa, Ontario (Liptak); College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA (Hollenbeck); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA (Maxwell, de Mello Souza); College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA (Wustefeld-Janssens).
Julius M LiptakDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA (Willette); Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA (Bini, Selmic); Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA (Traverson); Capital City Specialty & Emergency Animal Hospital, Ottawa, Ontario (Liptak); College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA (Hollenbeck); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA (Maxwell, de Mello Souza); College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA (Wustefeld-Janssens).
Danielle HollenbeckDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA (Willette); Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA (Bini, Selmic); Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA (Traverson); Capital City Specialty & Emergency Animal Hospital, Ottawa, Ontario (Liptak); College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA (Hollenbeck); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA (Maxwell, de Mello Souza); College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA (Wustefeld-Janssens).
Elizabeth A MaxwellDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA (Willette); Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA (Bini, Selmic); Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA (Traverson); Capital City Specialty & Emergency Animal Hospital, Ottawa, Ontario (Liptak); College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA (Hollenbeck); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA (Maxwell, de Mello Souza); College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA (Wustefeld-Janssens).
Carlos H de Mello SouzaDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA (Willette); Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA (Bini, Selmic); Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA (Traverson); Capital City Specialty & Emergency Animal Hospital, Ottawa, Ontario (Liptak); College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA (Hollenbeck); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA (Maxwell, de Mello Souza); College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA (Wustefeld-Janssens).
Brandan Wustefeld-JanssensDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA (Willette); Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA (Bini, Selmic); Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA (Traverson); Capital City Specialty & Emergency Animal Hospital, Ottawa, Ontario (Liptak); College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA (Hollenbeck); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA (Maxwell, de Mello Souza); College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA (Wustefeld-Janssens).
Laura SelmicDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA (Willette); Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA (Bini, Selmic); Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA (Traverson); Capital City Specialty & Emergency Animal Hospital, Ottawa, Ontario (Liptak); College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA (Hollenbeck); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA (Maxwell, de Mello Souza); College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA (Wustefeld-Janssens).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To compare cardiovascular outcomes in dogs undergoing adrenalectomy for pheochromocytoma with and without phenoxybenzamine pretreatment. Animals: A total of 65 medical records from dogs at 5 veterinary hospitals. Procedure: Records from January 2004 to December 2021 were evaluated for systolic, mean, and diastolic arterial pressures; numbers of hypertensive and hypotensive episodes; highest and lowest systolic arterial pressure differences; dose and duration of phenoxybenzamine; and presence of intraoperative arrhythmias. Phenoxybenzamine-pretreated dogs (Group PT, Results: Median (range) phenoxybenzamine dose was 0.46 (0.08 to 2.0) mg/kg, PO, q12h. Peak systolic and mean arterial pressures, lowest systolic and mean arterial pressures, duration of hypertension, duration of sinus tachycardia, number of hypotensive episodes, and duration of hypotension were not different between groups. More hypertensive episodes ( Conclusion: In dogs undergoing adrenalectomy for pheochromocytoma, phenoxybenzamine pretreatment as administered did not offer any cardiovascular benefits based on the measured variables, and may be associated with more intraoperative hypertensive episodes. Clinical relevance: Intraoperative changes in cardiovascular variables are prevalent in dogs with pheochromocytoma undergoing adrenalectomy. Further evaluation of pretreatment with phenoxybenzamine is needed to determine its role in these cases.

Indexed as

AdrenalectomyAdrenal Gland NeoplasmsDog DiseasesPhenoxybenzaminePheochromocytomaAnimalsBlood PressureDogsFemaleHypertensionHypotensionMaleRetrospective StudiesPhenoxybenzamine

Identifiers

PMID39649740
PMCPMC11618959

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.