ArticleFrontiers in aging neuroscience2024
Total burden of cerebral small vessel disease predict subjective cognitive decline in patients with Parkinson's disease.
Article in Frontiers in aging neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mediterranean diet and dementia: MRI marker evidence from meta-analysis.European journal of medical research · 2025Pooled it
- Triglyceride-glucose index is associated with cerebral small vessel disease-related motor impairment in Parkinson's disease: a mediation analysis.Frontiers in aging neuroscience · 2026Article
- Pathway Anchored Multimodal Clustering Reveals Circuit Level Signatures in Parkinsons Disease.bioRxiv : the preprint server for biology · 2025Article
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8 authors.
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Abstract
Introduction: This study investigates the correlation between the total burden of Cerebral Small Vessel Disease (CSVD) and Subjective Cognitive Decline (SCD) in patients with Parkinson's disease (PD). Methods: A cross-sectional design was employed, involving 422 patients with PD. Demographic and clinical data were collected. Brain magnetic resonance imaging (MRI) was conducted to identify CSVD markers. SCD was assessed using the Cognitive Complaints Inventory (CCI). Results: Logistic regression analyses revealed that the total burden of CSVD and specific imaging markers, including Deep White Matter Hyperintensities (DWMH), Periventricular Hyperintensities (PVH), and Enlarged Perivascular Spaces (EPVS), were significant predictors of SCD. The total burden of CSVD demonstrated the highest predictive accuracy for SCD in PD patients. Discussion: The findings suggest that the total burden of CSVD, as measured by MRI, could serve as a potential biomarker for early identification of cognitive decline in PD, highlighting the importance of considering vascular factors in the early detection of cognitive changes in PD.
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