Evidence map›Paper›PMID 39649583›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Anti-mitochondrial antibodies in systemic sclerosis target enteric neurons and are associated with GI dysmotility.

Zsuzsanna H McMahan, Livia Casciola-Rosen, Timothy Kaniecki, Laura Gutierrez-Alamillo, Su Hong Ming, Philippa Seika, Subhash Kulkarni

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Zsuzsanna H McMahanDivision of Rheumatology, UTHealth Houston, Houston, TX, United States.ORCID 0000-0001-6461-8940
Livia Casciola-RosenDivision of Rheumatology, Johns Hopkins University, Baltimore, MD, United States.
Timothy KanieckiDivision of Rheumatology, Johns Hopkins University, Baltimore, MD, United States.
Laura Gutierrez-AlamilloDivision of Rheumatology, Johns Hopkins University, Baltimore, MD, United States.
Su Hong MingDivision of Gastroenterology, Dept of Medicine, Beth Isreal Deaconess Medical Center, Boston, MA.
Philippa SeikaDivision of Gastroenterology, Dept of Medicine, Beth Isreal Deaconess Medical Center, Boston, MA.
Subhash KulkarniDivision of Gastroenterology, Dept of Medicine, Beth Israel Deaconess Medical Center, United States.ORCID 0000-0002-2298-0623

Funding

Sample Processing and Immunoassay Research CoreP30AR070254 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI Antony Rosen · 2016 to 2026
$8.9M
Autoantibodies Define Scleroderma Subgroups with Distinct Relationships to CancerR01AR073208 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI LIVIA A CASCIOLA-ROSEN, Ami Aalok Shah · 2018 to 2026
$5.2M
Identification of enteric Juvenile Protective Factors and their role in stimulating neurogenesis in the adult and ageing Enteric Nervous SystemR01AG066768 · NIA · JOHNS HOPKINS UNIVERSITY · PI GOFF, LOYAL ANDREW, KULKARNI, SUBHASH · 2021 to 2025
$3.3M
Interrogating the pathophysiological mechanisms of constipation in patients with systemic sclerosisR01AR081382 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Jiande Chen, Zsuzsanna Hortobagyi McMahan · 2023 to 2026
$2.4M
NIAMS NIH HHS P30 AR070254NIAMS NIH HHS R01 AR073208NIAMS NIH HHS R01 AR081382
6 · The paper itself

Abstract

Background: Most patients with systemic sclerosis (SSc) experience gastrointestinal (GI) dysmotility. The enteric nervous system (ENS) regulates GI motility, and its dysfunction causes dysmotility. A subset of SSc patients harbor autoantibodies against the M2 mitochondrial antigen (AM Methods: Sera from 154 well-characterized patients with SSc were screened for AM Results: Nineteen of 147 patients (12.9%) were AM Conclusion: AM

Identifiers

PMID39649583
PMCPMC11623719

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.