Evidence map›Paper›PMID 39649580›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Multi-ancestry genome-wide association study reveals novel genetic signals for lung function decline.

Bonnie K Patchen, Jingwen Zhang, Nathan Gaddis, Traci M Bartz, Jing Chen, Catherine Debban, Hampton Leonard, Ngoc Quynh Nguyen, Jungkun Seo, Courtney Tern and 26 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors.

Bonnie K PatchenDivision of Nutritional Sciences, Cornell University.ORCID 0000-0003-3361-6744
Jingwen ZhangBoston University School of Public Health, Boston, MA.
Nathan GaddisRTI International, Research Triangle Park, NC.
Traci M BartzCardiovascular Health Research Unit, Departments of Biostatistics, Medicine, Epidemiology, Health Systems and Population Health, University of Washington, Seattle, WA.
Jing ChenDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Catherine DebbanDepartment of Genome Sciences, University of Virginia School of Medicine, Charlottesville, VA.
Hampton LeonardLaboratory of Neurogenetics, National Institute of Aging, National Institute of Health, Bethesda, MD.
Ngoc Quynh NguyenSchool of Public Health, University of Texas Health Science Center, Houston, TX.
Jungkun SeoDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC.
Courtney TernChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA.
Richard AllenCollege of Life Sciences, University of Leicester, Leicester, UK.
Dawn L DeMeoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA.
Myriam FornageBrown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center, Houston, TX.
Carl MelbourneDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Melyssa MintoRTI International, Research Triangle Park, NC.
Matthew MollChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA.
George O'ConnorBoston University School of Medicine, Boston, MA.
Tess PottingerInstitute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Biostatistics, Medicine, Epidemiology, Health Systems and Population Health, University of Washington, Seattle, WA.
Stephen S RichDepartment of Genome Sciences, University of Virginia School of Medicine, Charlottesville, VA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA.
Edwin K SilvermanChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA.
Jeran StratfordRTI International, Research Triangle Park, NC.
R Graham BarrDepartment of Medicine, Columbia University College of Physicians and Surgeons, New York, NY.
Michael H ChoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA.ORCID 0000-0002-4907-1657
Sina A GharibDivision of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA.
Ani ManichaikulDepartment of Genome Sciences, University of Virginia School of Medicine, Charlottesville, VA.
Kari NorthDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC.
Elizabeth C OelsnerDepartment of Medicine, Columbia University College of Physicians and Surgeons, New York, NY.
Eleanor M SimonsickIntramural Research Program, National Institute on Aging, Baltimore, MD.
Martin D TobinDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Bing YuSchool of Public Health, University of Texas Health Science Center, Houston, TX.
Seung Hoan ChoiBoston University School of Public Health, Boston, MA.
Josee DupuisBoston University School of Public Health, Boston, MA.
Patricia A CassanoDivision of Nutritional Sciences, Cornell University.
Dana B HancockRTI International, Research Triangle Park, NC.

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9M
Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHGRI NIH HHS U01 HG004402NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201500014CNHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K23 HL130627NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC048047NHLBI NIH HHS N01 HC048048NHLBI NIH HHS N01 HC048049NHLBI NIH HHS N01 HC048050NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095095NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R21 HL129924NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG028050NIDDK NIH HHS P30 DK063491NINR NIH HHS R01 NR012459Wellcome Trust
6 · The paper itself

Abstract

Rationale: Accelerated decline in lung function contributes to the development of chronic respiratory disease. Despite evidence for a genetic component, few genetic associations with lung function decline have been identified. Objectives: To evaluate genome-wide associations and putative downstream functionality of genetic variants with lung function decline in diverse general population cohorts. Methods: We conducted genome-wide association study (GWAS) analyses of decline in the forced expiratory volume in the first second (FEV Measurements and Main Results: Our discovery analyses included 52,056 self-reported White (N=44,988), Black (N=5,788), Hispanic (N=550), and Chinese American (N=730) participants with a mean of 2.3 spirometry measurements and 8.6 years of follow-up. Functional mapping of GWAS meta-analysis results identified 361 distinct genome-wide significant (p<5E-08) variants in one or more of the FEV Conclusions: Our multi-ancestry GWAS meta-analyses identified numerous genetic loci associated with lung function decline. These findings contribute knowledge to the genetic architecture of lung function decline, provide evidence for a role of endogenous corticosteroids in the etiology of lung function decline, and identify drug targets that merit further study for potential repurposing to slow lung function decline and treat lung disease.

Indexed as

Chronic ObstructiveGenomicsLung Volume MeasurementsPulmonary DiseaseSpirometry

Identifiers

PMID39649580
PMCPMC11623738

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.