ArticleRestorative dentistry & endodontics2024
Evaluation of mineral induction ability and cytotoxicity of carbonated hydroxyapatite for pulp tissue regeneration: an
Article in Restorative dentistry & endodontics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Bioactivity and biocompatibility of bioceramic-based pulp capping materials in laboratory and animal models.Journal of materials science. Materials in medicine · 2025Article
- Advanced structural and compositional profiling of mineral trioxide aggregate incorporated with nano-carbonated hydroxyapatite: a comprehensive X-ray diffraction and energy dispersive X-ray investigation.Biomaterial investigations in dentistry · 2025Article
- Physicochemical and antibacterial evaluation of novel nano α-TCP-AgNPs biocomposites for direct pulp-capping applications.Frontiers in oral health · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: This study aimed to evaluate carbonated hydroxyapatite (CHA)'s ability for mineral induction and its Materials and Methods: Precursors for the study include di-ammonium hydrogen phosphate and calcium nitrate tetrahydrate, with sodium hydrogen carbonate added to achieve different levels of carbonate substitution. The synthesized CHA samples are characterized using X-ray diffraction, Fourier transform infrared spectroscopy, and Raman spectroscopy. Scanning electron microscopy (SEM) was used to observe morphology. For 14 days at 37°C, samples were submerged in simulated body fluid to assess their mineral induction capabilities. SEM was used to confirm apatite formation on sample surfaces. The cytotoxicity assay was used to assess the vitality of the cells following their exposure to various concentrations of CHA. Results: The Joint Committee on Powder Diffraction Standards data for HA aligned well with the results from X-ray diffraction analysis of CHA across 3 different concentrations, indicating strong agreement. Fourier transform infrared spectra indicated the presence of phosphate, hydroxyl, and carbonate groups within the samples. SEM and Energy-dispersive X-ray analysis show agglomerated and flaky nanoparticles. All the samples are bioactive, but the formation of apatite differs from one another. Conclusions: The results of this study may provide insight into the potential use of carbonated HA as a dental pulp-capping material for vital pulp therapy.
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Registered trials
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