ArticleMaterials today. Chemistry2021
Modulation of physical properties of organic cocrystals by amino acid chirality.
Article in Materials today. Chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Beyond Cocrystals: Hierarchical Functional Assemblies via Noncovalent Synthesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Design and Manufacturing of Piezoelectric Biomaterials for Bioelectronics and Biomedical Applications.Chemical reviews · 2025Review
- Enzymatic polymerization of enantiomericNature communications · 2023Article
- Co-Assembly Induced Solid-State Stacking Transformation in Amino Acid-Based Crystals with Enhanced Physical Properties.Angewandte Chemie (International ed. in English) · 2022Article
- A Piezoelectric Ionic Cocrystal of Glycine and Sulfamic Acid.Crystal growth & design · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Amino acid chirality plays an important role in conveying directionality and specificity to their supramolecular organization. However, the impact of enantiopure and racemic amino acids on the favorable packing and macroscopic properties of organic cocrystals with nonchiral coformers is poorly understood. Herein, we performed a systematic study of the effect of chirality on the macroscopic properties of acetylated alanine (AcA) single crystals and cocrystals with a nonchiral photo-sensitive bipyridine derivative (BPE). Cocrystallization with BPE produced a marked morphology transition that improved the supramolecular chirality, thermal stability and mechanical strength of AcA crystals. The distinct supramolecular packing modes were analyzed by X-ray crystallography. The highest rigidity was observed for BPE/DL-ACA, WHILE BPE/D-ACA AND BPE/L-ACA crystals exhibited higher efficiency of photo-induced emission for fluorescent imprinting, as well as significantly higher piezoelectricity. This work provides a striking illustration that subtle differences in amino acid stereochemistry translate into tunable macroscopic properties of organic cocrystals for future applications in rigid solids, fluorescent imprinting, and energy harvesting.
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Registered trials
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