ArticleInterface focus2024
Model-driven exploration of poro-viscoelasticity in human brain tissue: be careful with the parameters!
Article in Interface focus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential.Advanced healthcare materials · 2026Review
- Spatial scale of indentation explains shift in ratio between spinal cord gray and white matter stiffness.Scientific reports · 2026Article
- Primary Blast-Induced Traumatic Brain Injury as a Risk Factor for (Cerebro)vascular Disorder: Clinical Manifestations, Blast Physics, Biomechanics, Pathobiology, and Critical Gaps.International journal of molecular sciences · 2026Review
- Structure-Property-Function Relationships in Stimuli-Responsive Hydrogels for Brain Organoid Vascularization.Gels (Basel, Switzerland) · 2026Review
- Mechanobiology of hippocampal neurogenesis: directing neural stem cell fate through physical cues.Frontiers in molecular neuroscience · 2026Review
- Optimal experimental design for repeatable hyperelastic material characterization.Journal of the mechanical behavior of biomedical materials · 2025Article
- Mechanical characterization of brain tissue: experimental techniques, human testing considerations, and perspectives.Acta biomaterialia · 2025Review
- Evaluating the Performance and Repeatability of Poroelastic and Poroviscoelastic Models in Intrinsic MR Elastography.NMR in biomedicine · 2025Article
- Article
- The pulsing brain: state of the art and an interdisciplinary perspective.Interface focus · 2025Review
- Biointegration of soft tissue-inspired hydrogels on the chorioallantoic membrane: An experimental characterization.Materials today. Bio · 2025Article
- The pulsing brain: part I.Interface focus · 2024Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain is arguably the most complex human organ and modelling its mechanical behaviour has challenged researchers for decades. There is still a lack of understanding on how this multiphase tissue responds to mechanical loading and how material parameters can be reliably calibrated. While previous viscoelastic models with two relaxation times have successfully captured the response of brain tissue, the Theory of Porous Media provides a continuum mechanical framework to explore the underlying physical mechanisms, including interactions between solid matrix and free-flowing interstitial fluid. Following our previously published experimental testing protocol, here we perform finite element simulations of cyclic compression-tension loading and compression-relaxation experiments on human brain white and gray matter specimens. The solid volumetric stress proves to be a crucial factor for the overall biphasic tissue behaviour as it strongly interferes with porous effects controlled by the permeability. An inverse parameter identification reveals that poroelasticity alone is insufficient to capture the time-dependent material behaviour, but a poro-viscoelastic formulation captures the response of brain tissue well. We provide valuable insights into the individual contributions of viscous and porous effects. However, due to the strong coupling between porous, viscous, and volumetric effects, additional experiments are required to reliably determine all material parameters.
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