Evidence map›Paper›PMID 39649442›Full record

ReviewInfectious medicine2024

Vascular fibrosis and extracellular matrix remodelling in post-COVID 19 conditions.

Anna Kamdar, Robert Sykes, Cameron R Thomson, Kenneth Mangion, Daniel Ang, Michelle Aw Lee, Tom Van Agtmael, Colin Berry

Abstract readReview
In one paragraph

Review in Infectious medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. The Central Role of Macrophages in Long COVID Pathophysiology.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna KamdarSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow G12 8TA, UK.
Robert SykesSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow G12 8TA, UK.
Cameron R ThomsonSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow G12 8TA, UK.
Kenneth MangionSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow G12 8TA, UK.
Daniel AngSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow G12 8TA, UK.
Michelle Aw LeeSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow G12 8TA, UK.
Tom Van AgtmaelSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow G12 8TA, UK.
Colin BerrySchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow G12 8TA, UK.

Funding

British Heart Foundation FS/MBPHD/22/28011Chief Scientist Office COV/GLA/20/05Chief Scientist Office COV/LTE/20/10Medical Research Council MR/R005567/1
6 · The paper itself

Abstract

Causal associations between viral infections and acute myocardial injury are not fully understood, with mechanisms potentially involving direct cardiovascular involvement or systemic inflammation. This review explores plausible mechanisms of vascular fibrosis in patients with post-COVID-19 syndrome, focusing on extracellular matrix remodelling. Despite global attention, significant mechanistic or translational breakthroughs in the management of post-viral syndromes remain limited. No effective pharmacological or non-pharmacological interventions are currently available for patients experiencing persistent symptoms following COVID-19 infection. The substantial expansion of scientific knowledge resulting from collaborative efforts by medical experts, scientists, and government organisations in undertaking COVID-19 research could inform treatment strategies for other post-viral syndromes and respiratory illnesses. There is a critical need for clinical trials to evaluate potential therapeutic candidates, providing evidence to guide treatment decisions for post-COVID-19 syndromes.

Identifiers

PMID39649442
PMCPMC11621938

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.