ArticleFrontiers in pediatrics2024
The effect of haemoglobin and blood transfusion on preterm infant gut perfusion and injury.
Article in Frontiers in pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The relationship between erythrocyte transfusion in very preterm infants and inflammatory cytokines and morbidities: a prospective observational study.BMC pediatrics · 2026Observational
- Emerging evidence on the safety of enteral feeding during PRBC transfusion in preterm infants.Pediatric research · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: There is significant uncertainty regarding the role that anaemia or red blood cell transfusion (RBCT) plays in the development of gut injury in preterm infants. This study evaluated Near Infrared Spectroscopy (NIRS) together with a range of known biomarkers of gut inflammation to identify their relationship with anaemia and RBCT. Method: A prospective observational study of preterm infants born at <30 weeks gestation was conducted from birth until either 36 weeks post conceptional age or discharge home. Gut perfusion and biomarkers of gut injury were assessed weekly by: 60 min NIRS measurements (splanchnic tissue oxygenation index [sTOI] and fractional tissue oxygenation extraction [sFTOE]); stool calprotectin; urine intestinal and liver fatty acid binding proteins (I-FABPs and L-FABPs); and trefoil factor 3 (TFF-3). Exclusion criteria included Fetal Growth Restriction (FGR), and abnormal antenatal Dopplers. Haemoglobin (Hb) levels were measured in parallel with NIRS measurements. NIRS, together with urine and stool biomarkers of gut injury, were evaluated up to 72 h pre/post RBCT and pre/post measurements compared. Results: Forty-eight infants were studied. Median (range) gestational age was 26 Conclusion: There was no association between anaemia or RBCT with NIRS measurements of tissue oxygen saturation and biomarkers of intestinal inflammation or gut injury in preterm infants enrolled in this study. Further studies with standardised methods of examining the relationship between anaemia, RBCT and gut injury are needed.
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