Evidence map›Paper›PMID 39649385›Full record

ArticleMRS communications2024

Impact of coverage and guest residue on polyproline II helix peptide antifouling.

Rebecca S Ahn, Henry T Grome, Sogol Asaei, Geeta Verma, Christina S Dang, Harihara Baskaran, Julie N Renner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MRS communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rebecca S AhnDepartment of Chemical and Biomolecular Engineering, Case Western Reserve University, Cleveland, USA.
Henry T Grome *Department of Chemical and Biomolecular Engineering, Case Western Reserve University, Cleveland, USA.
Sogol Asaei *Department of Chemical and Biomolecular Engineering, Case Western Reserve University, Cleveland, USA.
Geeta VermaDepartment of Chemical and Biomolecular Engineering, Case Western Reserve University, Cleveland, USA.
Christina S DangDepartment of Chemical and Biomolecular Engineering, Case Western Reserve University, Cleveland, USA.
Harihara BaskaranDepartment of Chemical and Biomolecular Engineering, Case Western Reserve University, Cleveland, USA.
Julie N RennerDepartment of Chemical and Biomolecular Engineering, Case Western Reserve University, Cleveland, USA.ORCID 0000-0002-6140-4346

Funding

TR&D-4: Growing Tissue in the Scalable, Modular, Automated, and Closed (SMAC) FoundryP41EB021911 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI HARIHARA BASKARAN · 2016 to 2026
$13.9M
TRAINING PROGRAM IN MUSCULOSKELETAL RESEARCHT32AR007505 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI TRIOLO, RONALD J · 1986 to 2023
$6.3M
NIAMS NIH HHS T32 AR007505NIBIB NIH HHS P41 EB021911
6 · The paper itself

Abstract

Polyproline II (PPII) peptide sequences are recognized as promising biomaterials because of their attractive antifouling properties. However, the mechanisms behind their antifouling behavior have not been fully characterized. In this work we show that PPII peptide coverage, controlled by adsorption time, significantly reduces the fouling of bovine serum albumin (BSA, a model foulant). In addition, guest residues introduced into the PPII sequence are shown to significantly impact BSA adsorption as well as human mesenchymal stem cell (hMSC) spreading. This research will help guide future PPII peptide designs for incorporation into novel biomaterials. Graphical abstract: A guest residue system was utilized to understand properties that impact the ability of polyproline II helix peptide monolayers to resist the fouling of BSA and influence human mesenchymal cell spreading. Supplementary Information: The online version contains supplementary material available at 10.1557/s43579-024-00674-w.

Indexed as

AdhesionAdsorptionBiomaterialCoatingSurface chemistry

Identifiers

PMID39649385
PMCPMC11618189

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.