Evidence map›Paper›PMID 39648859›Full record

ArticleEmerging microbes & infections2025

Preassembled complexes of hAgo2 and ssRNA delivered by nanoparticles: a novel silencing gene expression approach overcoming the absence of the canonical pathway of siRNA processing in the apicomplexan parasite Babesia microti, blood parasite of veterinary and zoonotic importance.

Shimaa A E-S El-Sayed, Mohamed A Rizk, Hang Li, Uday Kumar Mohanta, Iqra Zafar, Shengwei Ji, Zhuowei Ma, Thom Do, Yongchang Li, Daisuke Kondoh and 2 more

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shimaa A E-S El-SayedNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Mohamed A RizkDepartment of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
Hang LiNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Uday Kumar MohantaNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Iqra ZafarNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Shengwei JiDepartment of Veterinary Medicine, Agriculture College of Yanbian University, Yanji, People's Republic of China.
Zhuowei MaNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Thom DoNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Yongchang LiNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Daisuke KondohDepartment of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Jerzy JaroszewskiDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Xuenan XuanNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to the lack of efficacy of the currently used chemical drugs, poor tick control, and lack of effective vaccines against

Indexed as

Argonaute ProteinsBabesia microtiBabesiosisNanoparticlesRNA, Small InterferingAnimalsErythrocytesGene SilencingHumansRNA InterferenceAGO2 protein, humanArgonaute ProteinsRNA, Small InterferingBabesiachitosan nanoparticlesgene delivery systemnoncanonical pathwayRNAi

Identifiers

PMID39648859
PMCPMC11721618

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.