ArticleThe Journal of international medical research2024
Causal association between glaucoma and risk of retinal vascular occlusion: a Mendelian randomization study.
Article in The Journal of international medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Clinical Implications of the Novel Genetic Polymorphism Associated With Retinal Vein Occlusion: The East Asian GWAS Survey in a Single-Center Taiwanese Cohort.Translational vision science & technology · 2026Article
- Unveiling Systemic Biomarkers and Metabolic Mechanisms in Glaucoma Progression from Multi-Omics Insights.International journal of molecular sciences · 2026Article
- Unraveling causal pathways in retinal vein occlusion: a systematic review of Mendelian randomization studies.International journal of retina and vitreous · 2025Review
- Exploring potential imaging biomarkers for ischemic retinal vein occlusion: insights from fundus autofluorescence and optical coherence tomography.Frontiers in medicine · 2025Article
- Intraocular pressure, primary open-angle glaucoma and the risk of retinal vein occlusion: A Mendelian randomization mediation analysis.Eye (London, England) · 2024Article
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Authors and funding
5 authors.
Funding
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Abstract
objectiveRetinal vein occlusion (RVO) leads to visual impairment, and risk factors may include glaucoma. Although some studies suggest a relationship between glaucoma and RVO, it is unknown whether this association is causal. We performed Mendelian randomization (MR) analyses to evaluate the causal contribution to RVO of five genetically predicted glaucoma conditions.
methodsWe conducted two-sample univariable MR analysis using inverse variance weighting, weighted median, and MR-Egger methods. We obtained publicly available datasets of genome-wide association studies (GWAS) meta-analyses for glaucoma as the exposure and a GWAS for RVO in the Finn Gen biobank study as the outcome.
resultsGenetically predicted glaucoma was causally associated with RVO risk (beta = 0.267, standard error [SE] = 0.052, odds ratio [OR] = 1.306, 95% confidence interval [CI]: 1.181-1.445). This association was supported by sensitivity analyses using weighted median (beta = 0.211, SE = 0.075, OR = 1.235, 95% CI: 1.067-1.429), weighted mode (beta = 0.491, SE = 0.132, OR = 1.633, 95% CI: 1.261-2.116), and MR-Egger (beta = 0.3900, SE = 0.138, OR = 1.476, 95% CI: 1.128-1.933) methods. MR analyses using the validation dataset obtained consistent results.
conclusionOur results indicated that glaucoma is likely causally associated with an increased risk of RVO. The current findings may help in determining the underlying mechanisms via which glaucoma affects the risk of RVO.
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