Evidence map›Paper›PMID 39648745›Full record

ArticleJournal of inherited metabolic disease2025

Circulatory response to exercise relative to oxygen uptake assessed in the follow-up of patients with fatty acid beta-oxidation disorders.

Apolline Imbard, Hortense de Calbiac, Edouard Le Guillou, Pascal Laforêt, Manuel Schiff, Anaïs Brassier, Elise Thevenet, Clément Pontoizeau, Bertrand Lefrère, Chris Ottolenghi and 8 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inherited metabolic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03802279 (Study of the Correlation Between the Effort Test, With the Assessment of Peripheral Oxygen Consumption and Cardiac Output in Patients With Acute Rhabdomyolysis Related to a Hereditary Disease of Metabolism, and the Biochemical Flux on Myoblasts), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03802279 completednot on this map

Study of the Correlation Between the Effort Test, With the Assessment of Peripheral Oxygen Consumption and Cardiac Output in Patients With Acute Rhabdomyolysis Related to a Hereditary Disease of Metabolism, and the Biochemical Flux on Myoblasts: Evaluate the Effort Test as a Therapeutic Monitoring Tool in Acute Rhabdomyolyses

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2019 to 2021Enrolled27ConditionsRhabdomyolysis Linked to a Hereditary Disease of MetabolismArmsEffort test, Functional tests on fibroblasts
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Multi-omic analysis reveals that theAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2026
    Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Apolline ImbardService de Biochimie, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.ORCID 0000-0002-0420-8322
Hortense de CalbiacINSERM U1151, Institut Necker Enfants-Malades (INEM), Paris, France.
Edouard Le GuillouService de Biochimie, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Pascal LaforêtService de Neurologie, CHU Paris IdF Ouest - Hôpital Raymond Poincaré, APHP, Garches, France.
Manuel SchiffUniversité Paris Cité, INSERM, Paris, France.
Anaïs BrassierCentre de référence des maladies héréditaires du métabolisme, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Institut Imagine, Filière G2M, MetabERN, Paris, France.
Elise ThevenetCentre de référence des maladies héréditaires du métabolisme, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Institut Imagine, Filière G2M, MetabERN, Paris, France.
Clément PontoizeauService de Biochimie, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Bertrand LefrèreService de Biochimie, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Chris OttolenghiService de Biochimie, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Elise LebigotService de Biochimie, Hôpital Universitaire Kremlin-Bicêtre, APHP, Le Kremlin-Bicêtre, France.
Pauline GaignardService de Biochimie, Hôpital Universitaire Kremlin-Bicêtre, APHP, Le Kremlin-Bicêtre, France.
Stéphanie GobinDépartement de Génétique, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Institut Imagine, Paris, France.
Cécile Acquaviva-BourdainLBMMS - Service Biochimie et Biologie Moléculaire, CHU de Lyon HCL - GH Est, Bron, France.
Jean-François BenoistService de Biochimie, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Caroline Tuchmann-DurandCentre de référence des maladies héréditaires du métabolisme, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Institut Imagine, Filière G2M, MetabERN, Paris, France.
Antoine LegendreCentre de référence Malformations Cardiaques Congénitales Complexes M3C - Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Pascale de LonlayINSERM U1151, Institut Necker Enfants-Malades (INEM), Paris, France.

Funding

Agence Nationale de la Recherche ANR-2013-BSV1-0020Agence Nationale de la Recherche ANR-2018 CE17Agence Nationale de la Recherche ANR-AAPG2023Association Française contre les Myopathies AFM 2012 (15947)Association Française contre les Myopathies AFM 2015 (19773)Association Française contre les Myopathies AFM 2022 (24269)Fondation Jerome LejeuneFondation Tango2Ultragenyx
6 · The paper itself

Abstract

Patients with fatty acid oxidation disorders (FAODs) experience muscle symptoms due to impaired ATP metabolism and the toxicity of accumulated mitochondrial FAO substrates or intermediates, especially during catabolic states. A major issue is the absence of specific and sensible biomarkers to evaluate metabolic equilibrium. The relationship between cardiac output (Q) and oxygen consumption (VO

Indexed as

CarnitineExerciseLipid Metabolism, Inborn ErrorsOxygen ConsumptionAdolescentAdultBiomarkersCardiac OutputCarnitine O-PalmitoyltransferaseChildExercise TestFatty AcidsFemaleFollow-Up StudiesHumansMaleacylcarnitineBiomarkersCarnitineCarnitine O-PalmitoyltransferaseFatty Acidsacylcarnitinecardiac outputexercise testfatty acid beta‐oxidation disorderoxygen consumptiontriheptanoin

Identifiers

PMID39648745
PMCPMC11670292

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.