Evidence map›Paper›PMID 39648651›Full record

ArticleCNS neuroscience & therapeutics2024

Mef2c Exacerbates Neuron Necroptosis via Modulating Alternative Splicing of Cflar in Ischemic Stroke With Hyperlipidemia.

Ruqi Li, Tianchen Huang, Jianpo Zhou, Xiansheng Liu, Gan Li, Yueman Zhang, Yunlu Guo, Fengshi Li, Yan Li, Arthur Liesz and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Ruqi LiCerebrovascular Diseases Center, Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-5878-2621
Tianchen HuangCerebrovascular Diseases Center, Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jianpo ZhouCerebrovascular Diseases Center, Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiansheng LiuCerebrovascular Diseases Center, Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Gan LiCerebrovascular Diseases Center, Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yueman ZhangDepartment of Anesthesiology, Key Laboratory of the Ministry of Education, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yunlu GuoDepartment of Anesthesiology, Key Laboratory of the Ministry of Education, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-6073-5947
Fengshi LiCerebrovascular Diseases Center, Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yan LiDepartment of Anesthesiology, Key Laboratory of the Ministry of Education, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Arthur LieszInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU, Munich, Germany.
Peiying LiDepartment of Anesthesiology, Key Laboratory of the Ministry of Education, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-5721-9914
Zhenghong WangDepartment of Anesthesiology, Key Laboratory of the Ministry of Education, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jieqing WanCerebrovascular Diseases Center, Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

Deutsche Forschungsgemeinschaft LI-2534/6-1Deutsche Forschungsgemeinschaft LI-2534/7-1National Natural Science Foundation of China 82071290National Natural Science Foundation of China 82171279National Natural Science Foundation of China 82371317National Natural Science Foundation of China M-0671National Natural Science Foundation of China U22A20295Pudong Health Committee of Shanghai PW2020E-2Science and Technology Innovation Plan Of Shanghai Science and Technology Commission 201409002500
6 · The paper itself

Abstract

aimHyperlipidemia is a common comorbidity of stroke patients, elucidating the mechanism that underlies the exacerbated ischemic brain injury after stroke with hyperlipidemia is emerging as a significant clinical problem due to the growing proportion of hyperlipidemic stroke patients.

methodsMice were fed a high-fat diet for 12 weeks to induce hyperlipidemia. Transient middle cerebral artery occlusion was induced as a mouse model of ischemic stroke. Emx1

resultsWe reported that hyperlipidemia significantly aggravated neuronal necroptosis and exacerbated long-term neurological deficits following ischemic stroke in mice. Mechanistically, Cflar, an upstream necroptotic regulator, was alternatively spliced into pro-necroptotic isoform (Cflar

conclusionsOur study highlights the pathogenic role of Cflar

Indexed as

Alternative SplicingHyperlipidemiasIschemic StrokeMEF2 Transcription FactorsNecroptosisNeuronsAnimalsCASP8 and FADD-Like Apoptosis Regulating ProteinMaleMiceMice, Inbred C57BLMice, TransgenicCASP8 and FADD-Like Apoptosis Regulating ProteinMef2c protein, mouseMEF2 Transcription Factorsalternative splicingCflarhyperlipidemiaMef2cnecroptosisstroke

Identifiers

PMID39648651
PMCPMC11625962

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.