Evidence map›Paper›PMID 39648520›Full record

ArticleEpigenetics2024

Epigenome-wide association study of loneliness in a sample of U.S. middle-aged twins.

Christopher R Beam, Kelly M Bakulski, Ebrahim Zandi, Eric Turkheimer, Morgan Lynch, Alaina I Gold, Thalida Em Arpawong, Sophie A Bell, Alyssa C Kam, Jonathan Becker and 1 more

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christopher R BeamDepartment of Psychology, University of Southern California, Los Angeles, USA.ORCID 0000-0001-6827-409X
Kelly M BakulskiSchool of Public Health, University of Michigan, Ann Arbor, USA.ORCID 0000-0002-9605-6337
Ebrahim ZandiKeck School of Medicine, University of Southern California, Los Angeles, USA.
Eric TurkheimerDepartment of Psychology, University of Virginia, Charlottesville, USA.
Morgan LynchDepartment of Psychology, University of Southern California, Los Angeles, USA.
Alaina I GoldDepartment of Psychology, University of Southern California, Los Angeles, USA.
Thalida Em ArpawongDavis School of Gerontology, University of Southern California, Los Angeles, USA.
Sophie A BellDepartment of Psychology, University of Virginia, Charlottesville, USA.
Alyssa C KamDepartment of Psychology, University of Southern California, Los Angeles, USA.
Jonathan BeckerDepartment of Family and Geriatric Medicine, University of Louisville, Louisville, USA.
Deborah Winders DavisDepartment of Pediatrics, University of Louisville, Louisville, USA.

Funding

Past, Present, and Future Risk of Cognitive Decline and Cognitive Impairment in the Louisville Twin StudyR01AG063949 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christopher Ryan Beam, DEBORAH WINDERS DAVIS · 2019 to 2026
$7.8M
DNA Methylation, Genetics, and Modifiable Risk Factors of Dementia in a Nationally Representative, Multi-Ethnic Cohort - Diversity SupplementR01AG067592 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAKULSKI, KELLY, WARE, ERIN BAKSHIS · 2020 to 2025
$3.8M
NIA NIH HHS R01 AG063949NIA NIH HHS R01 AG067592
6 · The paper itself

Abstract

Loneliness is a complex human trait that is highly polygenic and found to affect gene expression related to inflammatory and immunological functioning. To date, no epigenome-wide association studies of loneliness have tested whether differentially methylated sites are annotated to genes associated with inflammatory and immunological processes. Using 281 individual adult twins' DNA methylation data from the Louisville Twin Study, we performed an epigenome-wide analysis of loneliness to address this gap in the literature. In the discovery analysis, 169 twins were used to prioritize probes and test associations with DNA methylation age acceleration, and 56 independent monozygotic (MZ) twin pairs (112 individuals) were used in a within-family replication analysis. Among the 837,274 sites analyzed, no probe sites were statistically significant at the genome-wide level (

Indexed as

DNA MethylationEpigenomeGenome-Wide Association StudyLonelinessTwins, MonozygoticAdultCpG IslandsEpigenesis, GeneticFemaleHumansMaleMiddle AgedUnited StatesDNA methylationepigenetic clocksEpigeneticslonelinesssocial isolation

Identifiers

PMID39648520
PMCPMC11633227

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.