Evidence map›Paper›PMID 39648456›Full record

ReviewNMR in biomedicine2025

Systems Engineering Approach Towards Sensitive Cellular Fluorine-19 MRI.

Jiawen Chen, Piya Pal, Eric T Ahrens

Abstract readReview
In one paragraph

Review in NMR in biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Perfluoro-JACS Au · 2025
    Article
  6. Molecular imaging and biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jiawen ChenDepartment of Electrical and Computer Engineering, University of California, San Diego, La Jolla, California, USA.
Piya PalDepartment of Electrical and Computer Engineering, University of California, San Diego, La Jolla, California, USA.
Eric T AhrensDepartment of Radiology, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0001-6131-9304

Funding

Metallo-fluorocarbon nanoemulsion for PET detection of cancer inflammationR01CA279271 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ERIC T. AHRENS · 2023 to 2026
$2.6M
Imaging tumor-associated macrophages in head and neck squamous cell carcinoma using fluorine-19 MRIR01CA290014 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ERIC T. AHRENS, Joseph A Califano · 2024 to 2026
$2.0M
NCI NIH HHS R01 CA279271NCI NIH HHS R01 CA290014NIH HHS R01-CA27927NIH HHS R01-CA290014Office of Naval Research ONR-N000141912227
6 · The paper itself

Abstract

In vivo fluorine-19 MRI using F-based tracer media has shown utility and versatility for a wide range of biomedical uses, particularly immune and stem cell detection, as well as biosensing. As with many advanced MRI acquisition techniques, the sensitivity and limit of detection (LOD) in vivo is a key consideration for a successful study outcome. In this review, we analyze the primary factors that limit cell LOD. The achievable sensitivity is strongly dependent on the specific composition of tracer, cell type of interest, cell activity, data acquisition and reconstruction methods, and MRI hardware design. Recent innovations in molecular

Indexed as

Fluorine-19 Magnetic Resonance ImagingAnimalsFluorineHumansMagnetic Resonance ImagingFluorinechelatecompressed sensingfluorine‐19image processingimmune cellsmachine learningnanoemulsionperfluorocarbonpulse sequencesignal‐to‐noise ratio

Identifiers

PMID39648456
PMCPMC12863428

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.