Evidence map›Paper›PMID 39648282›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2025

Treatment trajectories among children and adolescents referred to the Norwegian National Center for Gender Incongruence.

Cecilie Bjertness Nyquist, Leila Torgersen, Linda W David, Trond Haaken Diseth, Kjersti Gulbrandsen, Anne Waehre

RetractedAbstract readRetracted Publication
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Cecilie Bjertness NyquistDivision of Paediatric and Adolescent Medicine, Department of Child and Adolescent Mental Health in Hospitals, Oslo University Hospital, Oslo, Norway.ORCID 0009-0002-8879-9234
Leila TorgersenDepartment of Child Health and Development, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0002-8164-1015
Linda W DavidDivision of Paediatric and Adolescent Medicine, Department of Child and Adolescent Mental Health in Hospitals, Oslo University Hospital, Oslo, Norway.ORCID 0000-0003-1444-1619
Trond Haaken DisethDivision of Paediatric and Adolescent Medicine, Department of Child and Adolescent Mental Health in Hospitals, Oslo University Hospital, Oslo, Norway.ORCID 0000-0003-1973-9369
Kjersti GulbrandsenDepartment of Gender Identity Assessment, Norwegian National Center for Gender Incongruence, Oslo University Hospital, Oslo, Norway.ORCID 0009-0007-3286-0880
Anne WaehreDivision of Paediatric and Adolescent Medicine, Department of Child and Adolescent Mental Health in Hospitals, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-5457-5606

Funding

Helse Sør-Øst RHF 2021033
6 · The paper itself

Abstract

aimWe aimed to describe treatment trajectories, detransition and mortality rate among children and adolescents referred to the Norwegian National Center for Gender Incongruence (NCGI).

methodsThe cohort included all 1258 persons under 18 years at referral to the NCGI from 2000 to 2020. Trajectories were registered until end of 2023.

resultsIn total, 861/1258 (68.4%) were assigned female gender at birth (AFAB). Mean age at referral was 14.4 years. Puberty suppression with gonadotropin-releasing hormone agonists (GnRHa) was initiated among 135/1258 (10.7%), significantly more persons assigned male gender at birth (AMAB) than AFAB (p < 0.001). Gender-affirming hormonal treatment (GAHT) was initiated in 783/1258 (62.2%). The continuation rate from GnRHa to GAHT was 97%. Discharge rate from NCGI without gender-affirming medical treatment among those who attended at least one appointment, was 264/1198 (22.0%). Eighteen AFAB detransitioned after initiated GAHT, eleven due to a cessation of transgender identity. Mortality rate in the cohort until end of 2023 was 11/1258 (0.9%).

conclusionDifferent trajectories including medical pathways and assessments without gender-affirming treatment were observed. GAHT was initiated in 783/1258 (62.2%), including eighteen AFAB detransitioning after testosterone treatment. There was a high continuation rate from GnRHa to GAHT. Various trajectories highlights the need for long-term follow-up in care.

Indexed as

Gender-Affirming ProceduresGender DysphoriaAdolescentChildCohort StudiesFemaleGonadotropin-Releasing HormoneHumansMaleNorwayReferral and ConsultationGonadotropin-Releasing Hormonedetransitiongender‐affirming treatmentgender dysphoriagender incongruence

Identifiers

PMID39648282
PMCPMC11976144

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.