Evidence map›Paper›PMID 39648251›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

The mediating role of processing speed on the relationship between executive functions and social cognition in relapsing-remitting multiple sclerosis patients.

Triantafyllos Doskas, Constantinos Kormas, Liberis Dekavallas, Christos Kokkotis, Anna Tsiakiri, Foteini Christidi, George Vavougios, Dimitrios Tsiptsios, Kanellos Spiliopoulos, Aspasia Serdari and 3 more

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Triantafyllos Doskas *Department of Neurology, Athens Naval Hospital, Athens, Greece.
Constantinos Kormas *Department of Neurology, Athens Naval Hospital, Athens, Greece. konkormas@med.uoa.gr.ORCID http://orcid.org/0000-0003-1313-8626
Liberis DekavallasDepartment of Neurology, Athens Naval Hospital, Athens, Greece.
Christos KokkotisDepartment of Physical Education and Sport Science, Democritus University of Thrace, Komotini, Greece.
Anna TsiakiriDepartment of Neurology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Foteini ChristidiDepartment of Neurology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
George VavougiosDepartment of Neurology, University of Cyprus, Nicosia, Cyprus.
Dimitrios TsiptsiosThird Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Kanellos SpiliopoulosDepartment of Neurology, Athens Naval Hospital, Athens, Greece.
Aspasia SerdariDepartment of Child and Adolescent Psychiatry, Medical School, Democritus University of Thrace, Komotini, Greece.
Nikolaos GrigoriadisSecond Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Ioannis IliopoulosDepartment of Neurology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Konstantinos VadikoliasDepartment of Neurology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study examined the mediating role of processing speed between executive functions and social cognition in 67 relapsing-remitting multiple sclerosis (RRMS) patients. Executive functions were assessed using the Trail Making Test-Part B (TMT-B) and the Stroop Neuropsychological Screening Test (SNST); social cognition with the Reading the Mind in the Eyes Test (RMET); and processing speed with the Symbol Digit Modalities Test (SDMT). Mediated effects were explored using a series of regression analyses and were further confirmed through bootstrapping procedures. Results revealed that processing speed partially mediated the relationship between cognitive shifting (TMT-B) and social cognition (RMET), and fully mediated the relationship between inhibitory control (SNST) and social cognition (RMET). These findings highlight the importance of processing speed in the socio-cognitive impairments observed in RRMS patients, thus suggesting that comprehensive assessments and targeted interventions in this clinical group.

Indexed as

Executive FunctionMultiple Sclerosis, Relapsing-RemittingSocial CognitionAdultFemaleHumansMaleMiddle AgedNeuropsychological TestsProcessing SpeedExecutive functionsMediation analysisMultiple sclerosisProcessing speedSocial cognition

Identifiers

PMID39648251

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.