Evidence map›Paper›PMID 39647667›Full record

ArticlePharmacology, biochemistry, and behavior2025

Mu-opioid receptor knockout on Foxp2-expressing neurons reduces aversion-resistant alcohol drinking.

Harrison M Carvour, Charlotte A E G Roemer, D'Erick P Underwood, Edith S Padilla, Oscar Sandoval, Megan Robertson, Mallory Miller, Natella Parsadanyan, Thomas W Perry, Anna K Radke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology, biochemistry, and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Harrison M CarvourDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Charlotte A E G RoemerDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
D'Erick P UnderwoodDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Edith S PadillaDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Oscar SandovalDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Megan RobertsonDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Mallory MillerDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Natella ParsadanyanDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Thomas W PerryDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA.
Anna K RadkeDepartment of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA. Electronic address: aradke@miamioh.edu.

Funding

Sex-specific effects of infant trauma on adult alcohol drinking: Role of amygdala intercalated neuronsR21AA028602 · NIAAA · MIAMI UNIVERSITY OXFORD · PI QUINN, JENNIFER J · 2021 to 2022
$368k
NIAAA NIH HHS R21 AA028602
6 · The paper itself

Abstract

Mu-opioid receptors (MORs) in the amygdala and striatum are important in addictive and rewarding behaviors. The transcription factor Foxp2 is a genetic marker of intercalated (ITC) cells in the amygdala and a subset of striatal medium spiny neurons (MSNs), both of which express MORs in wild-type mice and are neuronal subpopulations of potential relevance to alcohol-drinking behaviors. For the current series of studies, we characterized the behavior of mice with genetic deletion of the MOR gene Oprm1 in Foxp2-expressing neurons (Foxp2-Cre/Oprm1

Indexed as

Alcohol DrinkingAvoidance LearningForkhead Transcription FactorsNeuronsReceptors, Opioid, muRepressor ProteinsAnimalsConditioning, OperantFemaleMaleMiceMice, Inbred C57BLMice, KnockoutMorphineRewardForkhead Transcription FactorsFoxp2 protein, mouseMorphineOprm protein, mouseReceptors, Opioid, muRepressor ProteinsAlcoholAversion-resistanceFoxP2Knockout mouseMu-opioid receptor

Identifiers

PMID39647667
PMCPMC11769742

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.