Evidence map›Paper›PMID 39647365›Full record

ArticleDiabetes & metabolic syndrome

Study of the upper airway anatomy using magnetic resonance imaging in Indian obese patients with obstructive sleep apnea - A pilot study.

Sanjeev Sinha, Bhavesh Mohan Lal, Maskani Nithya, Renuka Titiyal, Soumyadeep Datta, Surabhi Vyas, Sandeep Aggarwal, Brandon Nokes, Atul Malhotra

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes & metabolic syndrome. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sanjeev SinhaDepartment of Medicine, All India Institute of Medical Sciences, New Delhi, India. Electronic address: drsanjeevsinha@gmail.com.
Bhavesh Mohan LalDepartment of Medicine, All India Institute of Medical Sciences, New Delhi, India.
Maskani NithyaDepartment of Medicine, All India Institute of Medical Sciences, New Delhi, India.
Renuka TitiyalDepartment of Medicine, All India Institute of Medical Sciences, New Delhi, India.
Soumyadeep DattaDepartment of Medicine, All India Institute of Medical Sciences, New Delhi, India.
Surabhi VyasDepartment of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India.
Sandeep AggarwalDepartment of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India.
Brandon NokesPulmonary, Critical Care and Sleep Medicine, UC San Diego School of Medicine, San Diego, 92121, CA, USA.
Atul MalhotraPulmonary, Critical Care and Sleep Medicine, UC San Diego School of Medicine, San Diego, 92121, CA, USA.

Funding

Is Obstructive Sleep Apnea Important in the Development of Alzheimer's DiseaseR01AG063925 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2020 to 2024
$3.7M
Underlying mechanisms of obesity-induced obstructive sleep apneaR01HL148436 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2020 to 2026
$3.4M
Sleep Apnea Endophenotypes: One Size Does Not Fit AllR01HL154926 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2021 to 2025
$3.3M
The cardiovascular consequences of sleep apnea plus COPD (Overlap syndrome)R01HL166485 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2023 to 2026
$3.1M
VentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19R01HL157985 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, NEMATI, SHAMIM · 2022 to 2025
$2.9M
Developing a Diverse Next Generation of Leaders in Respiratory ScienceT32HL166127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Laura Elise Crotty Alexander, Atul Malhotra · 2023 to 2026
$1.6M
NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R01 HL154926NHLBI NIH HHS R01 HL157985NHLBI NIH HHS R01 HL166485NHLBI NIH HHS T32 HL166127NIA NIH HHS R01 AG063925
6 · The paper itself

Abstract

backgroundObstructive sleep apnea (OSA) is very common in obese patients. However, why some obese patients have severe OSA while others do not is unclear. Research is limited regarding which structures contribute to upper airway narrowing, especially in Asian patients where bony restrictions is thought to be important.

methodsNineteen consecutive patients with BMI ≥35 kg/m

resultsPatients were divided into two groups, one with severe OSA comprising 11 patients and one without severe OSA having 8 patients. The retro-palatal airway was narrowest in both groups. Patients with severe OSA had a significantly narrower retroglossal airway (0.99 ± 0.48 cm

conclusionsWhile the retro-palatal airway is equally narrow in both groups of patients, patients with severe OSA also have a significantly narrower retro-glossal airway. This finding could represent either a generalized reduction in airway area in whole of the oropharynx or multiple-level obstruction; probably aggravating upper airway collapse during sleep, predisposing some Asian obese patients to develop severe OSA.

Indexed as

Magnetic Resonance ImagingObesityPolysomnographySleep Apnea, ObstructiveAdultFemaleFollow-Up StudiesHumansIndiaMaleMiddle AgedPalate, SoftPharynxPilot ProjectsPrognosisApnea-hypopnea indexMagnetic resonance imagingObstructive sleep apneaRetro-glossal airway

Identifiers

PMID39647365
PMCPMC11671282

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.