Evidence map›Paper›PMID 39645652›Full record

ArticleJournal of cosmetic dermatology2025

Treatment of Delayed Hypersensitivity After Injection of Nasal Fillers.

Liya Jiang, Fei Chen, Meiyang He, Yuejie Zhou, Qingqian Wei, Jintian Hu

Abstract readCase Reports
In one paragraph

Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Liya JiangDepartment of Cosmetic Injection Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Fei ChenThe First Clinical College, Guangzhou Medical University, Guangzhou, China.
Meiyang HeThe Third Clinical College, Guangzhou Medical University, Guangzhou, China.
Yuejie ZhouXi'an Jiaotong University, Xi'an, Shaanxi, China.
Qingqian WeiPlastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jintian HuDepartment of Cosmetic Injection Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID https://orcid.org/0000-0003-2036-2343

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSoft tissue filler injection is the second most commonly performed cosmetic procedure worldwide, with augmentation rhinoplasty being the most common filling surgery in Asian countries because Asians predominantly have a low nasal bridge. With the increasing pursuit of beauty, the adverse reactions after injection not only damage the patient's appearance but also greatly affect their quality of life. Therefore, exploring effective methods to address adverse reactions after nasal filler injections is necessary.

aimsHerein, we aimed to explore safe and effective drug doses and concentrations for the treatment of two patients who developed an allergic reaction after a nasal filling by intralesional drug injection.

methodsTwo patients developed severe swelling and deformity of the nose after the injection of fillers 6 months to 1 year prior to presentation. High-frequency ultrasound and local conditions revealed inflammation in the injected area. The patients were administered the combination of 0.7% triamcinolone acetonide, 0.42% 5-fluorouracil, and 0.7% lidocaine into the affected area; they were followed up for 6 months.

resultsAfter three times of treatment, swelling and sclerosis disappeared after 44.5 ± 2.12 days. No adverse effects of the infections were observed.

conclusionsThis drug regimen may represent a safe and effective therapeutic strategy for the treatment of complications after soft tissue filler injections.

Indexed as

Cosmetic TechniquesDermal FillersHypersensitivity, DelayedAdultAnesthetics, LocalDrug Therapy, CombinationFemaleHumansInjections, IntralesionalLidocaineMiddle AgedRhinoplastyTreatment OutcomeTriamcinolone AcetonideAnesthetics, LocalDermal FillersLidocaineTriamcinolone Acetonideaugmentation rhinoplastydelayed hypersensitivityfiller injectionhypersensitivityintralesional drug injection

Identifiers

PMID39645652
PMCPMC11845941

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.