ArticleArchives of virology2024
Molecular and ultrastructural characteristics of virulent and attenuated vaccine strains of goose parvovirus LIV-22.
Article in Archives of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The disease caused by goose parvovirus (GPV) affects young goslings and ducks and leads to substantial losses for farmers due to high mortality rates, reaching 70-100% in naive flocks. Here, we present the results of a study focusing on the historical virulent GPV LIV-22 strain, which was isolated in the USSR in 1972. An attenuated GPV LIV-22 vaccine strain that was generated by continuous passaging in goose embryonic fibroblasts was also studied. Phylogenetic analysis placed both GPV LIV-22 strains in the classical GPV group, close to the vaccine and low-pathogenic strains. However, several individual changes in the GPV LIV-22 VP1 gene highlight the uniqueness of the evolution and adaptation mechanism of GPV LIV-22 strains. Transmission electron microscopy (TEM) revealed severe ultrastructural changes in goose hepatocytes and enterocytes as early as 24-48 h postinfection, confirming abrupt GPV pathogenesis. This description of some of the essential characteristics of the GPV LIV-22 virulent and vaccine strain will be useful for studying GPV evolution and molecular pathogenesis.
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