Evidence map›Paper›PMID 39645621›Full record

Observational studyEuropean radiology2025

Loss of pulmonary capillaries in idiopathic pulmonary arterial hypertension with low diffusion capacity is accompanied by early diffuse emphysema detected by

Agilo Luitger Kern, Da-Hee Park, Jan Fuge, Jens M Hohlfeld, Frank Wacker, Marius M Hoeper, Karen M Olsson, Jens Vogel-Claussen

Abstract readObservational Study
In one paragraph

Observational study in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Diagnostic and management dilemmas in pulmonary hypertension.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  6. Functional Pulmonary Imaging.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Agilo Luitger Kern *Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
Da-Hee Park *Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany.
Jan FugeBiomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany.
Jens M HohlfeldBiomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany.
Frank WackerInstitute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
Marius M HoeperBiomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany.
Karen M OlssonBiomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany.
Jens Vogel-ClaussenInstitute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany. vogel-claussen.jens@mh-hannover.de.ORCID http://orcid.org/0000-0001-5595-6948

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesRecent studies suggest the existence of an idiopathic pulmonary arterial hypertension (IPAH) phenotype affecting mostly patients with a smoking history, characterised by low diffusion capacity for carbon monoxide (D MATERIALS AND

methodsBetween March 2019 and June 2023, patients of four groups were recruited for this observational study: IPAH with preserved (1) and low D

resultsTwenty-nine participants were recruited, of which 22 (age 64 ± 10, 11 male, 5/5/7/5 for the individual groups) could be included in the analysis. RBC-M and η were reduced in IPAH with low versus preserved D

conclusionResults are consistent with a loss of pulmonary capillaries in patients with IPAH and low D KEY POINTS: Question A loss of pulmonary capillaries has been suggested in patients with IPAH and low diffusion capacity without clinically significant emphysema on CT. Findings

Indexed as

CapillariesFamilial Primary Pulmonary HypertensionMagnetic Resonance ImagingPulmonary EmphysemaAgedFemaleHumansLungMaleMiddle AgedPulmonary Diffusing CapacityTomography, X-Ray ComputedXenon IsotopesXenon-129Xenon IsotopesMagnetic resonance imagingPulmonary arterial hypertensionPulmonary circulationPulmonary emphysemaXenon

Identifiers

PMID39645621
PMCPMC12081569

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.