Evidence map›Paper›PMID 39645441›Full record

ArticleCortex; a journal devoted to the study of the nervous system and behavior2025

Cognitive control & the anterior cingulate cortex: Necessity & coherence.

Lisa Cipolotti, Joe Mole, James K Ruffle, Amy Nelson, Robert Gray, Parashkev Nachev

Abstract readClinical Conference
In one paragraph

Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lisa CipolottiDepartment of Neuropsychology, National Hospital for Neurology and Neurosurgery, London, United Kingdom; Institute of Neurology, University College London, London, United Kingdom.
Joe MoleDepartment of Neuropsychology, National Hospital for Neurology and Neurosurgery, London, United Kingdom; Institute of Neurology, University College London, London, United Kingdom.
James K RuffleInstitute of Neurology, University College London, London, United Kingdom; Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom.
Amy NelsonInstitute of Neurology, University College London, London, United Kingdom.
Robert GrayInstitute of Neurology, University College London, London, United Kingdom.
Parashkev NachevInstitute of Neurology, University College London, London, United Kingdom. Electronic address: p.nachev@ucl.ac.uk.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Influential theories of complex behaviour invoke the notion of cognitive control modulated by conflict between counterfactual actions. Medial frontal cortex, notably the anterior cingulate cortex, has been variously posited as critical to such conflict detection, resolution, or monitoring, largely based on correlative data from functional imaging. Examining performance on the most widely used "conflict" task-Stroop-in a large cohort of patients with focal brain injury (N = 176), we compare anatomical patterns of lesion-inferred neural substrate dependence to those derived from functional imaging, meta-analytically summarised. Our results show that whereas performance is sensitive to the integrity of left lateral frontal regions implicated by functional imaging, it does not depend on medial frontal cortex, despite sampling adequate to reveal robust medial effects in the context of phonemic fluency. We suggest that medial frontal cortex is not critically invoked by Stroop and proceed to review the conceptual grounds for rejecting the core notion of conflict-driven cognitive control.

Indexed as

Brain InjuriesCognitionExecutive FunctionGyrus CinguliAdultAgedBrain MappingConflict, PsychologicalFemaleFrontal LobeHumansMagnetic Resonance ImagingMaleMiddle AgedStroop TestAnterior cingulate cortexCognitive controlConceptual analysisConflict detectionExecutive functionsNetwork lesion-deficit mappingStroop

Identifiers

PMID39645441
PMCPMC7618139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.