Evidence map›Paper›PMID 39644901›Full record

ArticleNeuron2025

Differential behavioral engagement of inhibitory interneuron subtypes in the zebra finch brain.

Ellie Hozhabri, Ariadna Corredera Asensio, Margot Elmaleh, Jeong Woo Kim, Matthew B Phillips, Paul W Frazel, Jordane Dimidschstein, Gord Fishell, Michael A Long

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Translational Potential of the Avian Cortex.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Review
  5. Modelling human brain development and disease with organoids.Nature reviews. Molecular cell biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ellie HozhabriNYU Neuroscience Institute and Department of Otolaryngology, New York University Langone Medical Center, New York, NY, USA; Center for Neural Science, New York University, New York, NY, USA.
Ariadna Corredera AsensioNYU Neuroscience Institute and Department of Otolaryngology, New York University Langone Medical Center, New York, NY, USA; Center for Neural Science, New York University, New York, NY, USA.
Margot ElmalehNYU Neuroscience Institute and Department of Otolaryngology, New York University Langone Medical Center, New York, NY, USA; Center for Neural Science, New York University, New York, NY, USA.
Jeong Woo KimNYU Neuroscience Institute and Department of Otolaryngology, New York University Langone Medical Center, New York, NY, USA; Center for Neural Science, New York University, New York, NY, USA.
Matthew B PhillipsNYU Neuroscience Institute and Department of Otolaryngology, New York University Langone Medical Center, New York, NY, USA; Center for Neural Science, New York University, New York, NY, USA.
Paul W FrazelNYU Neuroscience Institute and Department of Otolaryngology, New York University Langone Medical Center, New York, NY, USA; Center for Neural Science, New York University, New York, NY, USA.
Jordane DimidschsteinStanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Gord FishellStanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Michael A LongNYU Neuroscience Institute and Department of Otolaryngology, New York University Langone Medical Center, New York, NY, USA; Center for Neural Science, New York University, New York, NY, USA. Electronic address: mlong@med.nyu.edu.

Funding

Synaptic and circuit mechanisms of learned vocal productionR01NS075044 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MICHAEL A LONG · 2011 to 2026
$5.7M
NINDS NIH HHS R01 NS075044
6 · The paper itself

Abstract

Inhibitory interneurons are highly heterogeneous circuit elements often characterized by cell biological properties, but how these factors relate to specific roles underlying complex behavior remains poorly understood. Using chronic silicon probe recordings, we demonstrate that distinct interneuron groups perform different inhibitory roles within HVC, a song production circuit in the zebra finch forebrain. To link these functional subtypes to molecular identity, we performed two-photon targeted electrophysiological recordings of HVC interneurons followed by post hoc immunohistochemistry of subtype-specific markers. We find that parvalbumin-expressing interneurons are highly modulated by sensory input and likely mediate auditory gating, whereas a more heterogeneous set of somatostatin-expressing interneurons can strongly regulate activity based on arousal. Using this strategy, we uncover important cell-type-specific network functions in the context of an ethologically relevant motor skill.

Indexed as

BrainFinchesInterneuronsNeural InhibitionVocalization, AnimalAcoustic StimulationAnimalsMaleParvalbuminsSomatostatinParvalbuminsSomatostatinbehaviorbirdsongcircuitGABAergicinhibitoryinterneuronszebra finch

Identifiers

PMID39644901
PMCPMC11802303

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.