Evidence map›Paper›PMID 39644760›Full record

ArticleAddictive behaviors2025

Does cannabis substitute or complement alcohol after recreational cannabis legalization in the Washington State? A three-level mixed-effects modeling.

Yachen Zhu, Pamela J Trangenstein, William C Kerr

Abstract read
In one paragraph

Article in Addictive behaviors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Co-Use of Alcohol and Cannabis: How Are They Related?The American journal of psychiatry · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yachen ZhuAlcohol Research Group, Public Health Institute, 6001 Shellmound St, Suite 450, Emeryville, CA 94608, USA. Electronic address: yzhu@arg.org.
Pamela J TrangensteinAlcohol Research Group, Public Health Institute, 6001 Shellmound St, Suite 450, Emeryville, CA 94608, USA.
William C KerrAlcohol Research Group, Public Health Institute, 6001 Shellmound St, Suite 450, Emeryville, CA 94608, USA.

Funding

TREND &STRUCTURE OF ALCOHOL DEPENDENCE--GENERAL POPULATION 1990 SURVEY DATAP50AA005595 · NIAAA · WESTERN CONSORTIUM FOR PUBLIC HEALTH · PI MULIA, NINA · 1985 to 2025
$34.1M
Effects of Spirits Privatization on Alcohol Prices and Alcohol-related HarmsR01AA021742 · NIAAA · PUBLIC HEALTH INSTITUTE · PI KERR, WILLIAM C. · 2013 to 2017
$3.0M
Impacts of Recreational Marijuana Legalization and Retail Outlets in Washington: Unique Perspectives from Survey and County Mortality DataR01DA048526 · NIDA · PUBLIC HEALTH INSTITUTE · PI KERR, WILLIAM C. · 2019 to 2022
$2.0M
NIAAA NIH HHS P50 AA005595NIAAA NIH HHS R01 AA021742NIDA NIH HHS R01 DA048526
6 · The paper itself

Abstract

backgroundWhether cannabis substitute or complement alcohol remains inconclusive. Little is known about the daily-level associations between cannabis and alcohol use by cannabis user type (medical vs. recreational use) in people who use alcohol and cannabis within a legalized environment.

methodsAdult participants were from four waves of Washington Panel Survey during 2014-2016, who consumed both cannabis and alcohol in the past six months. Daily measurements of alcohol and cannabis use in the past week were collected at each wave. Our outcome variable was continuous alcoholic drinks, the exposure was any cannabis use. We applied three-level negative binomial models to account for within-person wave-to-wave and between-person variations, deriving pure within-person within-wave associations between cannabis and alcohol use at the daily level. A cross-level interaction between day-level cannabis use and wave-level medical cannabis recommendation investigated the potential differential substitution/complementarity patterns by medical recommendation status.

results259 respondents with 440 person-waves and 3,051 daily observations were included. We found a statistically significant pure Level 1 (within-person daily-level) effect of cannabis use among recreational cannabis users (IRR = 1.37, 95 % CI: 1.05-1.79, p = 0.02), showing a complementary use pattern. We also found a statistically significant cross-level interaction between medical cannabis recommendation and cannabis use at Level 1 (IRR = 0.57, 95 % CI: 0.34-0.96, p = 0.03), indicating that, differently from recreational users, medical cannabis users may have a substitution use pattern.

conclusionsCannabis user type may inform co-use patterns. This study suggested recreational cannabis users tended to use alcohol and cannabis in a complementary manner in Washington State following the legalization of recreational use.

Indexed as

Alcohol DrinkingMarijuana UseMedical MarijuanaAdolescentAdultFemaleHumansLegislation, DrugMaleMiddle AgedWashingtonYoung AdultMedical MarijuanaAlcohol useComplementarityMedical cannabis recommendationRecreational cannabis legalizationSubstitutionWashington State

Identifiers

PMID39644760
PMCPMC11725433

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.