Evidence map›Paper›PMID 39643920›Full record

ReviewEuropean eating disorders review : the journal of the Eating Disorders Association2025

Leptin Levels in Acute and Recovered Eating Disorders: An Arm-Based Network Meta-Analysis.

Emanuele Cassioli, Lorenzo Lucherini Angeletti, Eleonora Rossi, Giulia Selvi, Elena Riccardi, Serena Siviglia, Roberta Buonanno, Valdo Ricca, Giovanni Castellini

Abstract readReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Review in European eating disorders review : the journal of the Eating Disorders Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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  5. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emanuele CassioliPsychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0003-3623-7096
Lorenzo Lucherini AngelettiPsychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy.
Eleonora RossiPsychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0003-4755-3879
Giulia SelviPsychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy.
Elena RiccardiPsychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy.
Serena SivigliaPsychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy.
Roberta BuonannoPsychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy.
Valdo RiccaPsychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-9291-2124
Giovanni CastelliniPsychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0003-1265-491X

Funding

Università degli Studi di Firenze
6 · The paper itself

Abstract

objectiveThis study aimed to provide a BMI-adjusted meta-analytical calculation of blood leptin levels across different eating disorders (EDs) including anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED), recovered EDs, and healthy controls (HCs). The goal was to understand BMI-independent leptin alterations and their potential as biomarkers.

methodPubMed and ClinicalTrials.gov were searched for studies reporting serum leptin in AN, BN, BED, or recovered EDs. A multilevel network meta-analysis using a linear mixed-effects meta-regression model, adjusting for BMI, sex, and assay type, was performed on 146 studies (5048 patients, 3525 controls).

resultsSignificant differences in leptin levels were found across EDs. AN patients exhibited the lowest leptin levels, while BED patients had the highest. BN and recovered AN patients had leptin levels similar to AN, significantly lower than HCs. BMI, sex, and assay type were significant covariates. The model accounted for heterogeneity due to diagnostic criteria, assay types, and study-level differences.

conclusionsLeptin levels in EDs are significantly altered beyond BMI effects, suggesting disease-specific factors. These findings support leptin's potential as a biomarker for ED staging and prognosis. Further research is needed to explore leptin's role in ED pathogenesis and trajectory, to identify subpopulations and improve clinical interventions.

Indexed as

Feeding and Eating DisordersLeptinAnorexia NervosaBiomarkersBody Mass IndexBulimia NervosaHumansBiomarkersLeptinanorexia nervosabinge‐eating disorderbulimia nervosaleptinnetwork meta‐analysis

Identifiers

PMID39643920
PMCPMC11965547

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.