ArticleBMC psychiatry2024
Association between dyslipidemia and depression: a cross-sectional analysis of NHANES data from 2007 to 2018.
Article in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Article
- LDL-C modifies the association between triglycerides and depression identified by threshold scanning in US adults.Scientific reports · 2026Article
- The impact of the TyG index and psychosocial factors on depression in elderly non-diabetic patients with atrial fibrillation.Frontiers in psychiatry · 2026Article
- Association of pre-adolescent adverse childhood experiences with adolescent cholesterol levels: findings from the A-CHILD longitudinal study.Frontiers in public health · 2026Article
- Comorbidity Between Mood Disorders and Chronic Somatic Diseases, With a Focus on Cardiometabolic Disease, and Its Mechanistic Crosstalk.Depression and anxiety · 2026Review
- Gender specific associations and interactions of fat quality with sleep and mental health in the elderly.Journal of health, population, and nutrition · 2025Article
- Interactive effects of high-density lipoprotein cholesterol and insulin resistance on depression: results from the NHANES (2005-2018).Lipids in health and disease · 2025Article
- Prediction model for depression risk in middle-aged and elderly patients with metabolic syndrome: a nomogram and interpretable machine learning approach based on CHARLS.BMC psychiatry · 2025Article
- Triglycerides, Cholesterol, and Depressive Symptoms Among Undergraduate Medical Students: A Cross-Sectional Study.Diseases (Basel, Switzerland) · 2025Article
- Metabolic Modulators in Depression: Emerging Molecular Mechanisms and Therapeutic Opportunities.International journal of molecular sciences · 2025Review
- Predictive factors and risk model for depression in patients with type 2 diabetes mellitus: a comprehensive analysis of comorbidities and clinical indicators.Frontiers in endocrinology · 2025Article
- Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and the risk of early-onset post-stroke depression: a prospective study.Frontiers in neurology · 2025Article
- Antidepressant use and all-cause mortality in depressed individuals: A real-world cohort study.PloS one · 2025Article
- Development and Validation of a Machine Learning Model for Predicting Long-Term Depression Risk in ACS Patients After PCI: A Retrospective Cohort Study.International journal of general medicine · 2025Article
- Curvilinear relationship between life's crucial 9 and metabolic syndrome in U.S. adults: a cross-sectional study.Frontiers in endocrinology · 2025Article
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3 authors.
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Abstract
backgroundThe relationship between depression and dyslipidemia remains controversial, with inconsistent findings across studies. This study aimed to investigate the association between blood lipid levels and depression using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2018.
methodsThis cross-sectional study included 12,819 adult participants from NHANES. Depression was assessed using a nine-item depression screening instrument. Serum lipid levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), were measured using Roche modular P and Roche Cobas 6000 chemistry analyzers. Survey-weighted multiple logistic regression was used to assess the relationships between serum lipid levels and depression.
resultsWe observed a statistically significant negative association between HDL levels and depression (odds ratio [OR]: 0.72, 95% confidence interval [CI]: 0.58-0.90). After adjustments for covariates, HDL-C, TG, and the triglyceride glucose (TyG) index showed significant associations with depression (ORs: 0.66, 1.08, and 1.01, respectively). A linear correlation was observed between HDL-C levels and depression (P < 0.01), while TG levels and the TyG index exhibited nonlinear associations (p < 0.01 and p < 0.05, respectively). No significant positive associations were observed between increased TC or LDL-C levels and the risk of depression.
conclusionsHigh HDL-C levels were negatively associated with depression, while TG levels and the TyG index were positively associated with depression. Clinical attention should be given to the detection of lipid levels in patients with depression.
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