ArticleJournal of perinatology : official journal of the California Perinatal Association2025
Bifidobacterium longum subsp infantis (EVC001) is associated with reduced incidence of necrotizing enterocolitis stage ≥2 and bloody stools in premature babies.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Bifidobacteria: biogeography, host adaptation and ecological functions.Nature reviews. Microbiology · 2026Review
- Bifidobacterium modulates gut microbiota and aryl hydrocarbon receptor signaling in necrotizing enterocolitis rat model.Pediatric research · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
objectiveTo utilize an evidence-based probiotic protocol to achieve a 50% reduction in necrotizing enterocolitis (NEC) ≥ stage 2 and bloody stools. STUDY
designFrom January 2022 through September 2023, daily enteral Bifidobacterium longum ssp. infantis EVC001 (B. infantis EVC001) was administered to babies ≤ 33 6/7 weeks gestation until 36 weeks post menstrual age. Feeding tolerance and complications were compared to babies admitted during the prior two-year period. Fisher's Exact test was used to analyze proportional data and t test was used for continuous variables.
resultsA total of 265 babies received EVC001, and a total of 277 babies formed the pre-probiotic cohort. Probiotic use was associated with decreased NEC ≥ stage 2 (p = 0.0058), reduced bloody stools (p < 0.0001), decreased time to full enteral feeds (p < 0.0001), and decreased total parenteral nutrition (TPN) days (p < 0.0001).
conclusionAdministration of B. infantis EVC001 was associated with a decrease in NEC, a decrease in bloody stools, and improvement in feeding tolerance in premature babies.
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