Evidence map›Paper›PMID 39643604›Full record

ArticleNPJ digital medicine2024

Deep learning biomarker of chronometric and biological ischemic stroke lesion age from unenhanced CT.

Adam Marcus, Grant Mair, Liang Chen, Charles Hallett, Claudia Ghezzou Cuervas-Mons, Dylan Roi, Daniel Rueckert, Paul Bentley

Abstract read
In one paragraph

Article in NPJ digital medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adam MarcusDepartment of Brain Sciences, Imperial College London, London, UK.
Grant MairCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Liang ChenDepartment of Brain Sciences, Imperial College London, London, UK.
Charles HallettDepartment of Brain Sciences, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-6097-8164
Claudia Ghezzou Cuervas-MonsDepartment of Brain Sciences, Imperial College London, London, UK.
Dylan RoiDepartment of Brain Sciences, Imperial College London, London, UK.
Daniel RueckertDepartment of Computing, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-5683-5889
Paul BentleyDepartment of Brain Sciences, Imperial College London, London, UK. p.bentley@imperial.ac.uk.ORCID http://orcid.org/0000-0001-8036-7010

Funding

DH | National Institute for Health Research (NIHR) II-LA-0814-20007
6 · The paper itself

Abstract

Estimating progression of acute ischemic brain lesions - or biological lesion age - holds huge practical importance for hyperacute stroke management. The current best method for determining lesion age from non-contrast computerised tomography (NCCT), measures Relative Intensity (RI), termed Net Water Uptake (NWU). We optimised lesion age estimation from NCCT using a convolutional neural network - radiomics (CNN-R) model trained upon chronometric lesion age (Onset Time to Scan: OTS), while validating against chronometric and biological lesion age in external datasets (N = 1945). Coefficients of determination (R

Identifiers

PMID39643604
PMCPMC11624201

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.