Evidence map›Paper›PMID 39643110›Full record

Observational studyThe Journal of pediatrics2025

Association of a Count of Inpatient Morbidities with 2-Year Outcomes among Infants Born Extremely Preterm.

Rebecca A Dorner, Lei Li, Sara B DeMauro, Barbara Schmidt, Sahar Z Zangeneh, Yvonne Vaucher, Myra H Wyckoff, Susan Hintz, Waldemar A Carlo, Kathryn E Gustafson and 3 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00063063 (Generic Database), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00063063 recruitingnot on this map

Generic Database: A Survey of Morbidity and Mortality in Very Low Birth Weight Infants

TypeobservationalSponsorNICHD Neonatal Research NetworkRan1987 to 2030Enrolled80,000ConditionsInfant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, PrematureArmsNo Intervention
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rebecca A DornerNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA. Electronic address: Rebecca.dorner@sharp.com.
Lei LiBiostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC.
Sara B DeMauroDivision of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA.
Barbara SchmidtDivision of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
Sahar Z ZangenehBiostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC.
Yvonne VaucherNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA.
Myra H WyckoffDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
Susan HintzDivision of Neonatal and Developmental Medicine, Stanford University School of Medicine, Lucile Packard Children's Hospital Stanford, Palo Alto, CA.
Waldemar A CarloDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
Kathryn E GustafsonDepartment of Psychiatry and Behavioral Sciences, Department of Pediatrics, Duke University School of Medicine, Durham, NC.
Abhik DasBiostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC.
Anup KatheriaNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA.
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Funding

Neonatal Research Network Data Coordinating Center (DCC)U10HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 2008 to 2017
$62.3M
Duke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Data Ctr for the Cooperative Neonatal Research NetworkU01HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 1998 to 2007
$21.8M
The University of Rochester's Clinical and Translational Science InstituteUL1TR000042 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$14.4M
University of Iowa Clinical and Translational Science ProgramUL1TR000442 · NCATS · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2012 to 2013
$10.0M
Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E. · 2012 to 2014
$9.9M
University of New Mexico Clinical and Translational Science CenterUL1TR000041 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LARSON, RICHARD S · 2012 to 2014
$9.8M
Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1TR000093 · NCATS · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2012 to 2013
$6.5M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD021373 · NICHD · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI KENNEDY, KATHLEEN A · 1991 to 2015
$6.1M
Indiana Clinical and Translational Science Institute (UL1)UL1TR000006 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2012 to 2013
$5.6M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD027871 · NICHD · YALE UNIVERSITY · PI EHRENKRANZ, RICHARD A. · 1991 to 2012
$3.9M
NCATS NIH HHS UL1 TR000006NCATS NIH HHS UL1 TR000041NCATS NIH HHS UL1 TR000042NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR000093NCATS NIH HHS UL1 TR000442NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR001117NICHD NIH HHS U01 HD036790NICHD NIH HHS U10 HD021373NICHD NIH HHS U10 HD027871NICHD NIH HHS U10 HD036790NICHD NIH HHS U10 HD053119NICHD NIH HHS UG1 HD021364NICHD NIH HHS UG1 HD021385NICHD NIH HHS UG1 HD027851NICHD NIH HHS UG1 HD027853NICHD NIH HHS UG1 HD027856NICHD NIH HHS UG1 HD027880NICHD NIH HHS UG1 HD027904NICHD NIH HHS UG1 HD034216NICHD NIH HHS UG1 HD040492NICHD NIH HHS UG1 HD040689NICHD NIH HHS UG1 HD053089NICHD NIH HHS UG1 HD053109NICHD NIH HHS UG1 HD068244NICHD NIH HHS UG1 HD068263NICHD NIH HHS UG1 HD068270NICHD NIH HHS UG1 HD068278NICHD NIH HHS UG1 HD068284NICHD NIH HHS UG1 HD087226NICHD NIH HHS UG1 HD087229NICHD NIH HHS UG1 HD104252NICHD NIH HHS UG1 HD112100
6 · The paper itself

Abstract

objectiveTo determine if number of neonatal morbidities is associated with death or severe neurodevelopmental impairment (sNDI) among infants born extremely preterm who survived to 36 weeks' postmenstrual age (PMA). STUDY

designThis is a retrospective cohort analysis of prospectively collected data from 15 NICHD Neonatal Research Network centers. Neonatal morbidities and 2-year outcomes were examined for 3794 infants born at 22 to 26 weeks' gestation from 2014 through 2019 who survived to 36 weeks' PMA.

resultsSerious brain injury (SBI), bronchopulmonary dysplasia (BPD), and severe retinopathy of prematurity (ROP) had the strongest bivariate associations with death or sNDI (ORs, 95% CI): 3.96 (3.39, 4.64), 3.41 (2.94, 3.95), and 2.66 (2.28, 3.11)], respectively. A morbidity count variable was constructed using these morbidities. The estimated ORs and 95% CI for death or sNDI with any 1, any 2, or all 3 of these morbidities, adjusted for maternal and infant characteristics and hospital of birth, increased from 2.75 (2.25, 3.37) to 6.10 (4.83, 7.70) to 12.90 (9.07, 18.36), respectively. Corresponding rates of late death or sNDI with none, any 1, any 2, and all 3 morbidities were 12.6%, 30.3%, 51.9%, and 69.9%, respectively. The estimated logistic model produced predictions of death or sNDI with moderate discrimination (C-statistic [95% CI]: 0.765 [0.749, 0.782]) and good calibration (Intercept [CITL] = -0.004, slope = 1.026).

conclusionsAmong infants born extremely preterm who survived to 36 weeks' PMA, a count of SBI, BPD, and severe ROP predicts death or sNDI.

trial registrationClinicalTrials.gov ID Generic Database: NCT00063063.

Indexed as

Brain InjuriesBronchopulmonary DysplasiaInfant, Extremely PrematureInfant, Premature, DiseasesNeurodevelopmental DisordersFemaleGestational AgeHumansInfantInfant, NewbornMaleMorbidityRetinopathy of PrematurityRetrospective Studiesdeathextremely low gestational age newbornsextremely pretermneonatal intensive careneonatal research network (NRN)neurodevelopmental impairmentprediction tool

Identifiers

PMID39643110
PMCPMC11867846

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.