Evidence map›Paper›PMID 39642885›Full record

ArticleCell stem cell2025

Human adult neurogenesis loss corresponds with cognitive decline during epilepsy progression.

Aswathy Ammothumkandy, Luis Corona, Kristine Ravina, Victoria Wolseley, Jeremy Nelson, Nadiya Atai, Aidin Abedi, Nora Jimenez, Michelle Armacost, Lina M D'Orazio and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Aswathy AmmothumkandyDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Luis CoronaDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Kristine RavinaNeurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Victoria WolseleyDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Physiology & Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Jeremy NelsonDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Nadiya AtaiNeurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Aidin AbediNeurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Nora JimenezLos Angeles General Medical Center, Los Angeles, CA 90033, USA.
Michelle ArmacostDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA 90242, USA.
Lina M D'OrazioDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Virginia Zuverza-ChavarriaDepartment of Psychology, Rancho Los Amigos National Rehabilitation Center, Downey, CA 90242, USA.
Alisha CayceDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Carol McClearyDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
George NuneNeurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Laura KalayjianDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Darrin J LeeNeurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Brian LeeNeurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Robert H ChowDepartment of Physiology & Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, USA; Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Christianne HeckNeurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Jonathan J RussinNeurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Charles Y LiuNeurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, USA. Electronic address: cliu@usc.edu.
Jason A D SmithNeurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Neurology, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: smijaso1@musc.edu.
Michael A BonaguidiDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Neurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, USA; Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Biochemistry and Molecular Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Gerontology, University of Southern California, Los Angeles, CA 90089, USA. Electronic address: mbonagui@usc.edu.

Funding

Evaluation of Cellular Heterogeneity Using Patchclamp and RNA-Seq of Single CellsU01MH098937 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHOW, ROBERT HSIU-PING, KNOWLES, JAMES A · 2012 to 2016
$8.6M
Neural stem cell rejuvenation through single cell pharmacogenomicsR01AG076956 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MICHAEL Bonaguidi · 2022 to 2026
$3.9M
Mechanisms Underlying Adult Neural Stem Cell HomeostasisR56AG064077 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BONAGUIDI, MICHAEL · 2019 to 2019
$611k
NIA NIH HHS R01 AG076956NIA NIH HHS R56 AG064077NIMH NIH HHS U01 MH098937
6 · The paper itself

Abstract

Mesial temporal lobe epilepsy (MTLE) is a syndromic disorder presenting with seizures and cognitive comorbidities. Although seizure etiology is increasingly understood, the pathophysiological mechanisms contributing to cognitive decline and epilepsy progression remain less recognized. We have previously shown that adult hippocampal neurogenesis dramatically declines in MTLE patients with increased disease duration. Here, we investigate when multiple cognitive domains become affected during epilepsy progression and how human neurogenesis levels contribute to it. We find that intelligence, verbal learning, and memory decline at a critical period of 20 years disease duration. In contrast to rodents, the number of human immature neurons positively associates with auditory verbal, rather than visuospatial, learning and memory. Moreover, this association does not apply to mature granule neurons. Our study provides cellular evidence of how adult neurogenesis corresponds with human cognition and signifies an opportunity to advance regenerative medicine for patients with MTLE and other cognitive disorders.

Indexed as

Cognitive DysfunctionEpilepsyEpilepsy, Temporal LobeNeurogenesisAdultDisease ProgressionFemaleHippocampusHumansMaleMiddle AgedNeuronscognitionco-morbiditycritical perioddementiaepilepsyhuman adult neurogenesisimmature neuronlearningmemoryneural stem cellprogressive disorder

Identifiers

PMID39642885
PMCPMC12807443

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.