Evidence map›Paper›PMID 39642856›Full record

ArticleMolecular cell2024

Reactive oxygen species control protein degradation at the mitochondrial import gate.

Rachael McMinimy, Andrew G Manford, Christine L Gee, Srividya Chandrasekhar, Gergey Alzaem Mousa, Joelle Chuang, Lilian Phu, Karen Y Shih, Christopher M Rose, John Kuriyan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Mass spectrometry proteomics for studying mitostasis.Protein science : a publication of the Protein Society · 2026
    Review
  5. Review
  6. Redox signals and oxidative stress in the control of mitochondrial protein import.Protein science : a publication of the Protein Society · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Localized heme sensing through a ternary molecular glue.bioRxiv : the preprint server for biology · 2026
    Article
  13. Quality control of protein import into mammalian mitochondria.Protein science : a publication of the Protein Society · 2026
    Review
  14. Function and regulation of the mitochondrial stress response.Nature structural & molecular biology · 2026
    Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rachael McMinimyDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Andrew G ManfordDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA, USA.
Christine L GeeDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA, USA; California Institute for Quantitative Biosciences (QB3), University of California at Berkeley, Berkeley, CA 94720, USA.
Srividya ChandrasekharDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Gergey Alzaem MousaHelen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, CA 94720, USA.
Joelle ChuangDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Lilian PhuGenentech Inc. South San Francisco, South San Francisco, CA 94080, USA.
Karen Y ShihDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
Christopher M RoseGenentech Inc. South San Francisco, South San Francisco, CA 94080, USA.
John KuriyanDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA, USA.
Baris BingolGenentech Inc. South San Francisco, South San Francisco, CA 94080, USA.
Michael RapéDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA, USA; California Institute for Quantitative Biosciences (QB3), University of California at Berkeley, Berkeley, CA 94720, USA. Electronic address: mrape@berkeley.edu.

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Ritimukta Sarangi · 2020 to 2026
$43.3M
Function and regulation of the reductive stress responseR01GM151335 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Michael P Rape · 2023 to 2026
$1.2M
Automated High-Throughput, High-Content Confocal/Wide-Field Microscope SystemS10OD021828 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI WEST, MARY · 2017 to 2017
$1.0M
LTQ XL Linear Quadrupole Ion Trap Mass SpectrometerS10RR025622 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI KOHLSTAEDT, LORI · 2009 to 2009
$463k
NCRR NIH HHS S10 RR025622NIGMS NIH HHS P30 GM133894NIGMS NIH HHS R01 GM151335NIH HHS S10 OD021828
6 · The paper itself

Abstract

While reactive oxygen species (ROS) have long been known to drive aging and neurodegeneration, their persistent depletion below basal levels also disrupts organismal function. Cells counteract loss of basal ROS via the reductive stress response, but the identity and biochemical activity of ROS sensed by this pathway remain unknown. Here, we show that the central enzyme of the reductive stress response, the E3 ligase Cullin 2-FEM1 homolog B (CUL2

Indexed as

MitochondriaProteolysisReactive Oxygen SpeciesAnimalsCullin ProteinsElectron Transport Complex IIIElectron Transport Complex IVHEK293 CellsHumansMitochondrial Precursor Protein Import Complex ProteinsOxidative StressCullin ProteinsElectron Transport Complex IIIElectron Transport Complex IVMitochondrial Precursor Protein Import Complex ProteinsReactive Oxygen Specieselectron transport chainFEM1Bmitochondriaproteasomereductive stress responseTOM complexubiquitin

Identifiers

PMID39642856
PMCPMC11649020

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.