Evidence map›Paper›PMID 39642691›Full record

ArticleEuropean journal of medicinal chemistry2025

High potency 3-carboxy-2-methylbenzofuran pendrin inhibitors as novel diuretics.

Riya J Master, Joy Karmakar, Peter M Haggie, Joseph Anthony-Tan, Tifany Chu, Alan S Verkman, Marc O Anderson, Onur Cil

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Riya J MasterDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Joy KarmakarDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Peter M HaggieDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Joseph Anthony-TanDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Tifany ChuDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Alan S VerkmanDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Marc O AndersonDepartment of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA, USA.
Onur CilDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA. Electronic address: onur.cil@ucsf.edu.

Funding

SLC26A3 (DRA) Inhibitors for Treatment of Hyperoxaluria and NephrolithiasisR01DK126070 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CIL, ONUR · 2020 to 2024
$1.6M
Roles of CaSR in ocular surface health and diseaseR01EY036139 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Onur Cil · 2024 to 2026
$1.2M
NEI NIH HHS R01 EY036139NIDDK NIH HHS R01 DK126070
6 · The paper itself

Abstract

Pendrin (SLC26A4) is an anion exchanger expressed in epithelial cells of kidney and lung. Pendrin inhibition is a potential treatment approach for edema, hypertension and inflammatory lung diseases. We have previously identified first-in-class pendrin inhibitors by high-throughput screening, albeit with low potency for pendrin inhibition (IC

Indexed as

BenzofuransDiureticsSulfate TransportersAnimalsAnion Transport ProteinsDose-Response Relationship, DrugHumansMaleMiceMolecular StructureStructure-Activity RelationshipAnion Transport ProteinsBenzofuransDiureticsSLC26A4 protein, humanSlc26a4 protein, mouseSulfate TransportersAsthmaBenzofuranCystic fibrosisEdemaHypertensionSLC26A4

Identifiers

PMID39642691
PMCPMC13011504

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.