Evidence map›Paper›PMID 39642577›Full record

ReviewClinics (Sao Paulo, Brazil)2025

Personalized nutrition and precision medicine in perimenopausal women: A minireview of genetic polymorphisms COMT, FUT2, and MTHFR.

Pedro Andrade, Aline Boveto Santamarina, Jéssica Alves de Freitas, Annete Bressan Rente Ferreira Marum, Ana Flávia Marçal Pessoa

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinics (Sao Paulo, Brazil), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pedro AndradeInstituto Medicina e Nutrição de Precisão, São Paulo, Brazil; Laboratório de Parasitologia Médica (LIM-46), Departamento de Doenças Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP 05403-000, Brazil.
Aline Boveto SantamarinaLaboratório de Produtos e Derivados Naturais, Laboratório de Investigação Médica-26 (LIM-26), Departamento de Cirurgia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP 01246903, Brazil.
Jéssica Alves de FreitasLaboratório de Produtos e Derivados Naturais, Laboratório de Investigação Médica-26 (LIM-26), Departamento de Cirurgia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP 01246903, Brazil; Laboratório de Parasitologia Médica (LIM-46), Departamento de Doenças Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP 05403-000, Brazil.
Annete Bressan Rente Ferreira MarumInstituto Medicina e Nutrição de Precisão, São Paulo, Brazil; Paulista School of Medicine, Federal University of São Paulo - UNIFESP, São Paulo, SP 04021-001, Brazil; Laboratório de Parasitologia Médica (LIM-46), Departamento de Doenças Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP 05403-000, Brazil.
Ana Flávia Marçal PessoaLaboratório de Produtos e Derivados Naturais, Laboratório de Investigação Médica-26 (LIM-26), Departamento de Cirurgia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP 01246903, Brazil; Laboratório de Parasitologia Médica (LIM-46), Departamento de Doenças Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP 05403-000, Brazil; Botânio Pesquisa e Desenvolvimento Ltda, São Paulo, SP 05545010, Brazil. Electronic address: anabiorq@usp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This mini-review explores the potential of precision medicine and personalized nutrition in addressing health challenges faced by perimenopausal women, focusing on the role of genetic polymorphisms in key metabolic pathways. Specifically focus on the single nucleotide polymorphisms (SNPs) in the COMT, FUT2, and MTHFR genes, which influence neurotransmitter metabolism, gut microbiota composition, and folate homeostasis, respectively. These polymorphisms are critical in modulating hormonal fluctuations, metabolic imbalances, and nutrient absorption during perimenopause. The review highlights the impact of COMT rs4680 on stress response and mood disorders, FUT2 rs602662 and rs601338 on vitamin B12 absorption and cortisol metabolism, and MTHFR rs1801133 and rs1801131 on homocysteine levels and cardiovascular risk. Furthermore, the integration of machine learning in precision medicine is discussed, offering insights into how genetic data can optimize personalized interventions. This approach enables targeted nutritional and therapeutic strategies to mitigate the metabolic and psychological effects of perimenopause. Overall, this review underscores the importance of incorporating genetic testing into preventive care for perimenopausal women to enhance quality of life and promote healthy aging.

Indexed as

Catechol O-MethyltransferaseFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseMethylenetetrahydrofolate Reductase (NADPH2)PerimenopausePolymorphism, Single NucleotidePrecision MedicineFemaleHumansCatechol O-MethyltransferaseCOMT protein, humanFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanCOMT geneFUT2 geneMTHFR genePerimenopauseSingle nucleotide polymorphismVitamins B complex

Identifiers

PMID39642577
PMCPMC11664282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.