Evidence map›Paper›PMID 39642539›Full record

ArticleComputational biology and chemistry2025

Machine learning approaches for predicting craniofacial anomalies with graph neural networks.

Colten Alme, Harun Pirim, Yusuf Akbulut

Abstract read
In one paragraph

Article in Computational biology and chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Colten AlmeMechanical Engineering, North Dakota State University, United States of America.
Harun PirimIndustrial and Manufacturing Engineering, North Dakota State University, United States of America. Electronic address: harun.pirim@ndsu.edu.
Yusuf AkbulutIndustrial and Manufacturing Engineering, North Dakota State University, United States of America.

Funding

Research CoresP20GM103442 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI Donald A. Sens · 2012 to 2026
$53.0M
NIGMS NIH HHS P20 GM103442
6 · The paper itself

Abstract

This study explores the use of machine learning algorithms, including traditional approaches and graph neural networks (GNNs), to predict certain diseases by analyzing protein-protein interactions. Protein-protein interactions (PPIs) are complex, multifaceted, and sometimes ever-changing. Therefore, analyzing PPIs and making predictions based on them present significant challenges to traditional computational techniques. However, machine learning, particularly GNNs, with their powerful ability to identify complex patterns within large, convoluted datasets, emerge as compelling and revolutionary tools for unraveling these intricate biological networks. We apply machine learning, aided by SHAP explainability and GNNs, on three networks of distinct sizes, ranging from small to large. While the ML results highlight the higher importance of network features in prediction, GNNs exhibit superior accuracy.

Indexed as

Craniofacial AbnormalitiesMachine LearningNeural Networks, ComputerGraph Neural NetworksHumansProtein Interaction MapsCraniofacial anomaliesGraph neural networksMachine learningSHAP

Identifiers

PMID39642539
PMCPMC11850188

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.